Perucca, P., Dubeau, F. & Gotman, J. Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology. Brain 137, 183–196 (2014).
Modur, P. N. High frequency oscillations and infraslow activity in epilepsy. Ann. Indian Acad. Neurol. 17, S99–S106 (2014).
Revankar, G. S. et al. in Seizures in Critical Care: A Guide to Diagnosis and Therapeutics (eds Varelas, P. N. and Claassen, J.) 77–90 (Humana Press, 2017); https://doi.org/10.1007/978-3-319-49557-6_5
Dreier, J. P. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat. Med. 17, 439–447 (2011).
Google Scholar
Staba, R. J., Stead, M. & Worrell, G. A. Electrophysiological biomarkers of epilepsy. Neurotherapeutics 11, 334–346 (2014).
Google Scholar
Dell, K. L., Cook, M. J. & Maturana, M. I. Deep brain stimulation for epilepsy: biomarkers for optimization. Curr. Treat. Options Neurol. 21, 47 (2019).
Kuhlmann, L., Lehnertz, K., Richardson, M. P., Schelter, B. & Zaveri, H. P. Seizure prediction—ready for a new era. Nat. Rev. Neurol. 14, 618–630 (2018).
Chari, A., Thornton, R. C., Tisdall, M. M. & Scott, R. C. Microelectrode recordings in human epilepsy: a case for clinical translation. Brain Commun. 2, fcaa082 (2020).
Lee, S. et al. DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone. Seizure 77, 52–58 (2020).
Li, C. et al. Evaluation of microelectrode materials for direct-current electrocorticography. J. Neural Eng. 13, 16008 (2015).
Hartings, J. A. How slow can you go? Nat. Mater. 18, 194–196 (2019).
Google Scholar
Major, S., Gajovic-Eichelmann, N., Woitzik, J. & Dreier, J. P. Oxygen-induced and pH-induced direct current artifacts on invasive platinum/iridium electrodes for electrocorticography. Neurocrit. Care 35, 146–159 (2021).
Khodagholy, D. et al. In vivo recordings of brain activity using organic transistors. Nat. Commun. 4, 1575 (2013).
Kostarelos, K., Vincent, M., Hebert, C. & Garrido, J. A. Graphene in the design and engineering of next-generation neural interfaces. Adv. Mater. 29, 1700909 (2017).
Blaschke, B. M. et al. Mapping brain activity with flexible graphene micro-transistors. 2D Mater. 4, 025040 (2017).
Hébert, C. et al. Flexible graphene solution-gated field-effect transistors: efficient transducers for micro-electrocorticography. Adv. Funct. Mater. 28, 1703976 (2017).
Masvidal-Codina, E. et al. High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors. Nat. Mater. 18, 280–288 (2019).
Google Scholar
Weltman, A., Yoo, J. & Meng, E. Flexible, penetrating brain probes enabled by advances in polymer microfabrication. Micromachines 7, 180 (2016).
Tien, L. W. et al. Silk as a multifunctional biomaterial substrate for reduced glial scarring around brain-penetrating electrodes. Adv. Funct. Mater. 23, 3185–3193 (2013).
Google Scholar
Coenen, A. M. L. & Van Luijtelaar, E. L. J. M. Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behav. Genet. 33, 635–655 (2003).
Google Scholar
Terlau, J. et al. Spike-wave discharges in absence epilepsy: segregation of electrographic components reveals distinct pathways of seizure activity. J. Physiol. https://doi.org/10.1113/JP279483 (2020).
Zijlmans, M. et al. High-frequency oscillations as a new biomarker in epilepsy. Ann. Neurol. 71, 169–178 (2012).
Jacobs, J. et al. High-frequency oscillations (HFOs) in clinical epilepsy. Prog. Neurobiol. 98, 302–315 (2012).
Google Scholar
Ikeda, A. et al. Focal ictal direct current shifts in human epilepsy as studied by subdural and scalp recording. Brain 122, 827–838 (1999).
Wu, S. et al. Role of ictal baseline shifts and ictal high-frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures. Epilepsia 55, 690–698 (2014).
Vanhatalo, S. et al. Very slow EEG responses lateralize temporal lobe seizures: an evaluation of non-invasive DC-EEG. Neurology 60, 1098–1104 (2003).
Google Scholar
Duan, X. et al. Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor. Nat. Nanotechnol. 7, 174–179 (2012).
Google Scholar
Hess, L. H. Graphene transistors for biosensing and bioelectronics. Proc. IEEE 101, 1780–1792 (2013).
Google Scholar
Hess, L. H. et al. High-transconductance graphene solution-gated field effect transistors. Appl. Phys. Lett. 99, 033503 (2011).
Garcia-Cortadella, R. et al. Distortion-free sensing of neural activity using graphene transistors. Small 16, 1906640 (2020).
Google Scholar
Lecomte, A. et al. Silk and PEG as means to stiffen a parylene probe for insertion in the brain: toward a double time-scale tool for local drug delivery. J. Micromech. Microeng. 25, 125003 (2015).
Fueta, Y. & Avoli, M. Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus. Epilepsy Res. 12, 207–215 (1992).
Google Scholar
Padmanabhan, K. & Urban, N. N. Disrupting information coding via block of 4-AP-sensitive potassium channels. J. Neurophysiol. 112, 1054–1066 (2014).
Google Scholar
Zakharov, A., Chernova, K., Burkhanova, G., Holmes, G. L. & Khazipov, R. Segregation of seizures and spreading depolarization across cortical layers. Epilepsia 60, 2386–2397 (2019).
Google Scholar
Hartings, J. A. et al. Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations. J. Cereb. Blood Flow Metab. 37, 1857–1870 (2017).
Harriott, A. M., Takizawa, T., Chung, D. Y. & Chen, S. P. Spreading depression as a preclinical model of migraine. J. Headache Pain 20, 45 (2019).
Buzsáki, G. & Lopes da Silva, F. L High frequency oscillations in the intact brain. Prog. Neurobiol. 98, 241–249 (2012).
Ikeda, A. et al. Active direct current (DC) shifts an “Red slow”: two new concepts for seizure mechanisms and identification of the epileptogenic zone. Neurosci. Res. 156, 95–101 (2020).
Kamarajan, C., Pandey, A. K., Chorlian, D. B. & Porjesz, B. The use of current source density as electrophysiological correlates in neuropsychiatric disorders: a review of human studies. Int. J. Psychophysiol. 97, 310–322 (2015).
Flynn, S. P., Barrier, S., Scott, R. C., Lenck-Santini, P. P. & Holmes, G. L. Status epilepticus induced spontaneous dentate gyrus spikes: in vivo current source density analysis. PLoS ONE 10, e0132630 (2015).
Coenen, A. M. L. & Van Luijtelaar, E. L. J. M. The WAG/Rij rat model for absence epilepsy: age and sex factors. Epilepsy Res. 1, 297–301 (1987).
Google Scholar
Orlowska-Feuer, P. et al. Infra-slow modulation of fast beta/gamma oscillations in the mouse visual system. J. Physiol. 599, 1631–1650 (2021).
Google Scholar
Garcia-Cortadella, R. et al. Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity. Nat. Commun. 12, 211 (2021).
Google Scholar
Bahari, F. et al. Seizure-associated spreading depression is a major feature of ictal events in two animal models of chronic epilepsy. Preprint at bioRxiv https://doi.org/10.1101/455519 (2020).
Dreier, J. P. et al. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain 135, 259–275 (2012).
Dreier, J. P. et al. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group. J. Cereb. Blood Flow Metab. 37, 1595–1625 (2017).
De Tisi, J. et al. The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. Lancet 378, 1388–1395 (2011).
Kanazawa, K. et al. Intracranially recorded ictal direct current shifts may precede high frequency oscillations in human epilepsy. Clin. Neurophysiol. 126, 47–59 (2015).
Lauritzen, M. et al. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J. Cereb. Blood Flow Metab. 31, 17–35 (2011).
Schaefer, N. et al. Improved metal-graphene contacts for low-noise, high-density microtransistor arrays for neural sensing. Carbon 161, 647–655 (2020).
Google Scholar
Jin, H. J. et al. Water-stable silk films with reduced β-sheet content. Adv. Funct. Mater. 15, 1241–1247 (2005).
Google Scholar
Rockwood, D. N. et al. Materials fabrication from Bombyx mori silk fibroin. Nat. Protoc. 6, 1612–1631 (2011).
Google Scholar
Vepari, C. & Kaplan, D. L. Silk as a biomaterial. Prog. Polym. Sci. 32, 991–1007 (2007).
Google Scholar
Cao, Y. & Wang, B. Biodegradation of silk biomaterials. Int. J. Mol. Sci. 10, 1514–1524 (2009).
Google Scholar
Gobin, A. S., Froude, V. E. & Mathur, A. B. Structural and mechanical characteristics of silk fibroin and chitosan blend scaffolds for tissue regeneration. J. Biomed. Mater. Res. A 74, 465–473 (2005).
Russo, E. et al. Upholding WAG/Rij rats as a model of absence epileptogenesis: hidden mechanisms and a new theory on seizure development. Neurosci. Biobehav. Rev. 71, 388–408 (2016).
Google Scholar
van Luijtelaar, G. & van Oijen, G. Establishing drug effects on electrocorticographic activity in a genetic absence epilepsy model: advances and pitfalls. Front. Pharmacol. 11, 395 (2020).
Google Scholar

