Caliari, S. R. & Burdick, J. A. A practical guide to hydrogels for cell culture. Nat. Methods 13, 405–414 (2016).
Google Scholar
Lin, W. et al. Cartilage-inspired, lipid-based boundary-lubricated hydrogels. Science 370, 335–338 (2020).
Google Scholar
Zheng, L. et al. Intensified stiffness and photodynamic provocation in a collagen-based composite hydrogel drive chondrogenesis. Adv. Sci. 6, 1900099 (2019).
Contessotto, P. et al. Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep. Sci. Transl. Med. 13, eaaz5380 (2021).
Google Scholar
Hogrebe, N. J., Reinhardt, J. W. & Gooch, K. J. Biomaterial microarchitecture: a potent regulator of individual cell behavior and multicellular organization. J. Biomed. Mater. Res. A 105, 640–661 (2017).
Google Scholar
Zhang, X. et al. Physically and chemically dual-crosslinked hydrogels with superior mechanical properties and self-healing behavior. N. J. Chem. 44, 9903–9911 (2020).
Google Scholar
Kim, S. et al. In situ mechanical reinforcement of polymer hydrogels via metal-coordinated crosslink mineralization. Nat. Commun. 12, 667 (2021).
Google Scholar
Rauner, N., Meuris, M., Zoric, M. & Tiller, J. C. Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics. Nature 543, 407–410 (2017).
Google Scholar
Meng, Z. et al. Light-triggered in situ gelation to enable robust photodynamic-immunotherapy by repeated stimulations. Adv. Mater. 31, 1900927 (2019).
Lim, S. H. & Mao, H. Q. Electrospun scaffolds for stem cell engineering. Adv. Drug Deliv. Rev. 61, 1084–1096 (2009).
Google Scholar
Huang, F. et al. Spatiotemporal patterning of photoresponsive DNA-based hydrogels to tune local cell responses. Nat. Commun. 12, 2364 (2021).
Google Scholar
Daly, A. C., Davidson, M. D. & Burdick, J. A. 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels. Nat. Commun. 12, 753 (2021).
Google Scholar
Chung, B. G., Lee, K. H., Khademhosseini, A. & Lee, S. H. Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering. Lab Chip 12, 45–59 (2012).
Google Scholar
Chaudhuri, O. et al. Substrate stress relaxation regulates cell spreading. Nat. Commun. 6, 6364 (2015).
Google Scholar
Wei, Q. et al. Soft hydrogels for balancing cell proliferation and differentiation. ACS Biomater. Sci. Eng. 6, 4687–4701 (2020).
Google Scholar
Chen, W. W. et al. Probing the role of integrins in keratinocyte migration using bioengineered extracellular matrix mimics. ACS Appl. Mater. Interfaces 9, 36483–36492 (2017).
Google Scholar
Madl, C. M. et al. Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling. Nat. Mater. 16, 1233–1242 (2017).
Google Scholar
Parmar, P. A. et al. Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells. Biomaterials 99, 56–71 (2016).
Google Scholar
Wang, J. K. et al. Interpenetrating network of alginate-human adipose extracellular matrix hydrogel for islet cells encapsulation. Macromol. Rapid Commun. 41, 2000275 (2020).
Google Scholar
Matera, D. L. et al. Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation. Sci. Adv. 6, eabb5069 (2020).
Google Scholar
Vegas, A. J. et al. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat. Biotechnol. 34, 345–352 (2016).
Google Scholar
Reid, S. E. et al. Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO J. 36, 2373–2389 (2017).
Google Scholar
Olivares-Navarrete, R. et al. Substrate stiffness controls osteoblastic and chondrocytic differentiation of mesenchymal stem cells without exogenous stimuli. PLoS ONE 12, e0170312 (2017).
Google Scholar
Farooque, T. M. et al. Measuring stem cell dimensionality in tissue scaffolds. Biomaterials 35, 2558–2567 (2014).
Google Scholar
Bao, M., Xie, J., Piruska, A. & Huck, W. T. S. 3D microniches reveal the importance of cell size and shape. Nat. Commun. 8, 1962 (2017).
Google Scholar
Zhong, W. et al. YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity. J. Mol. Histol. 44, 587–595 (2013).
Google Scholar
Chaudhuri, O. et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat. Mater. 15, 326–334 (2015).
Google Scholar
Bauer, A. et al. Hydrogel substrate stress-relaxation regulates the spreading and proliferation of mouse myoblasts. Acta Biomater. 62, 82–90 (2017).
Google Scholar
Schoenenberger, A. D., Foolen, J., Moor, P., Silvan, U. & Snedeker, J. G. Substrate fiber alignment mediates tendon cell response to inflammatory signaling. Acta Biomater. 71, 306–317 (2018).
Google Scholar
Hsia, H. C., Nair, M. R., Mintz, R. C. & Corbett, S. A. The fiber diameter of synthetic bioresorbable extracellular matrix influences human fibroblast morphology and fibronectin matrix assembly. Plast. Reconstr. Surg. 127, 2312–2320 (2011).
Google Scholar
Anderson, S. B., Lin, C. C., Kuntzler, D. V. & Anseth, K. S. The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 32, 3564–3574 (2011).
Google Scholar
Rousselle, P. & Scoazec, J. Y. Laminin 332 in cancer: When the extracellular matrix turns signals from cell anchorage to cell movement. Semin. Cancer Biol. 62, 149–165 (2019).
Google Scholar
Wan, A. M. et al. Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells. Biochim. Biophys. Acta 1830, 4314–4320 (2013).
Google Scholar
Kim, H., Cha, J., Jang, M. & Kim, P. Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte/macrophage. Biomater. Sci. 7, 2264–2271 (2019).
Google Scholar
Caliari, S. R. et al. Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation. Sci. Rep. 6, 21387 (2016).
Google Scholar
Ondeck, M. G. et al. Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling. Proc. Natl Acad. Sci. USA 116, 3502–3507 (2019).
Google Scholar
Guvendiren, M. & Burdick, J. A. Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics. Nat. Commun. 3, 792 (2012).
Google Scholar
Rape, A. D., Zibinsky, M., Murthy, N. & Kumar, S. A synthetic hydrogel for the high-throughput study of cell-ECM interactions. Nat. Commun. 6, 8129 (2015).
Google Scholar
Yang, B. et al. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics. Nat. Commun. 12, 3514 (2021).
Google Scholar
Ahearne, M. Introduction to cell-hydrogel mechanosensing. Interface Focus 4, 20130038 (2014).
Google Scholar
Anselme, K., Ploux, L. & Ponche, A. Cell/material interfaces: Influence of surface chemistry and surface topography on cell adhesion. J. Adhes. Sci. Technol. 24, 831–852 (2010).
Google Scholar
Silva, L. P. et al. Neovascularization induced by the hyaluronic acid-based spongy-like hydrogels degradation products. ACS Appl. Mater. Interfaces 8, 33464–33474 (2016).
Google Scholar
Mitura, S., Sionkowska, A. & Jaiswal, A. Biopolymers for hydrogels in cosmetics: review. J. Mater. Sci. Mater. Med. 31, 50 (2020).
Google Scholar
Brandenberg, N. et al. High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays. Nat. Biomed. Eng. 4, 863–874 (2020).
Google Scholar
Kong, B. et al. Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma. Nat. Commun. 11, 1435 (2020).
Google Scholar
Hyung, S. et al. A 3D disease and regeneration model of peripheral nervous system-on-a-chip. Sci. Adv. 7, eabd9749 (2021).
Google Scholar
LeSavage, B. L. & Heilshorn, S. C. Defined matrices bring IBD to 3D. Nat. Mater. 20, 124–125 (2021).
Google Scholar
Tsou, Y. H., Khoneisser, J., Huang, P. C. & Xu, X. Hydrogel as a bioactive material to regulate stem cell fate. Bioact. Mater. 1, 39–55 (2016).
Google Scholar
Farhat, W. et al. Hydrogels for advanced stem cell therapies: a biomimetic materials approach for enhancing natural tissue function. IEEE Rev. Biomed. Eng. 12, 333–351 (2019).
Google Scholar
Xu, L. et al. Hydrogel materials for the application of islet transplantation. J. Biomater. Appl. 33, 1252–1264 (2019).
Google Scholar
Ye, S., Boeter, J. W. B., Penning, L. C., Spee, B. & Schneeberger, K. Hydrogels for liver tissue engineering. Bioengineering 6, 59 (2019).
Google Scholar
Blache, U. & Ehrbar, M. Inspired by nature: hydrogels as versatile tools for vascular engineering. Adv. Wound Care 7, 232–246 (2018).
Cheung, A. S., Zhang, D. K. Y., Koshy, S. T. & Mooney, D. J. Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells. Nat. Biotechnol. 36, 160–169 (2018).
Google Scholar
Wu, D. et al. NK-cell-encapsulated porous microspheres via microfluidic electrospray for tumor immunotherapy. ACS Appl. Mater. Interfaces 11, 33716–33724 (2019).
Google Scholar
Yang, P. et al. Engineering dendritic-cell-based vaccines and PD-1 blockade in self-assembled peptide nanofibrous hydrogel to amplify antitumor T-cell immunity. Nano Lett. 18, 4377–4385 (2018).
Google Scholar
DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19, 369–382 (2019).
Google Scholar
Weiden, J., Tel, J. & Figdor, C. G. Synthetic immune niches for cancer immunotherapy. Nat. Rev. Immunol. 18, 212–219 (2018).
Google Scholar
Sun, Z. et al. Injectable hydrogels coencapsulating granulocyte-macrophage colony-stimulating factor and ovalbumin nanoparticles to enhance antigen uptake efficiency. ACS Appl. Mater. Interfaces 10, 20315–20325 (2018).
Google Scholar
Gao, W., Zhang, Y., Zhang, Q. & Zhang, L. Nanoparticle-hydrogel: a hybrid biomaterial system for localized drug delivery. Ann. Biomed. Eng. 44, 2049–2061 (2016).
Google Scholar
Hoare, T. R. & Kohane, D. S. Hydrogels in drug delivery: progress and challenges. Polymer 49, 1993–2007 (2008).
Google Scholar
Li, J. & Mooney, D. J. Designing hydrogels for controlled drug delivery. Nat. Rev. Mater. 1, 16071 (2016).
Google Scholar
Wang, F. et al. Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel. Nat. Biomed. Eng. 4, 1090–1101 (2020).
Google Scholar
Liu, X., Sun, X. & Liang, G. Peptide-based supramolecular hydrogels for bioimaging applications. Biomater. Sci. 9, 315–327 (2021).
Google Scholar
Bae, J. et al. Tailored hydrogels for biosensor applications. J. Ind. Eng. Chem. 89, 1–12 (2020).
Google Scholar
Khajouei, S., Ravan, H. & Ebrahimi, A. DNA hydrogel-empowered biosensing. Adv. Colloid Interface Sci. 275, 102060 (2020).
Google Scholar
Cai, Y. et al. Mixed-dimensional MXene-hydrogel heterostructures for electronic skin sensors with ultrabroad working range. Sci. Adv. 6, eabb5367 (2020).
Google Scholar
Deng, J. et al. Electrical bioadhesive interface for bioelectronics. Nat. Mater. 20, 229–236 (2021).
Google Scholar
Cascone, S. & Lamberti, G. Hydrogel-based commercial products for biomedical applications: a review. Int. J. Pharm. 573, 118803 (2020).
Google Scholar
Caló, E. & Khutoryanskiy, V. V. Biomedical applications of hydrogels: a review of patents and commercial products. Eur. Polym. J. 65, 252–267 (2015).
Mandal, A., Clegg, J. R., Anselmo, A. C. & Mitragotri, S. Hydrogels in the clinic. Bioeng. Transl. Med. 5, e10158 (2020).
Google Scholar
Sahiner, N., Singh, M., De Kee, D., John, V. T. & McPherson, G. L. Rheological characterization of a charged cationic hydrogel network across the gelation boundary. Polymer 47, 1124–1131 (2006).
Google Scholar
Malik, R., Lelkes, P. I. & Cukierman, E. Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol. 33, 230–236 (2015).
Google Scholar
Gasser, T. C. In Biomechanics of Living Organs (eds. Payan, Y. & Ohayon, J.) 169–191 (2017).
Davidenko, N. et al. Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry. J. Mater. Sci. Mater. Med. 27, 148 (2016).
Google Scholar
Lee, P. F., Bai, Y., Smith, R. L., Bayless, K. J. & Yeh, A. T. Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffness. Acta Biomater. 9, 7178–7190 (2013).
Google Scholar
Liang, Y. et al. A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity. Biomaterials 32, 9308–9315 (2011).
Google Scholar
Gaudet, I. D. & Shreiber, D. I. Characterization of methacrylated type-I collagen as a dynamic, photoactive hydrogel. Biointerphases 7, 25 (2012).
Google Scholar
Gasperini, L., Mano, J. F. & Reis, R. L. Natural polymers for the microencapsulation of cells. J. R. Soc. Interface 11, 20140817 (2014).
Google Scholar
Nichol, J. W. et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31, 5536–5544 (2010).
Google Scholar
Yang, C. et al. The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J. Biol. Chem. 287, 43094–43107 (2012).
Google Scholar
Cui, N., Qian, J., Zhao, N. & Wang, H. Functional hyaluronic acid hydrogels prepared by a novel method. Mater. Sci. Eng. C Mater. Biol. Appl. 45, 573–577 (2014).
Google Scholar
Griesser, J., Hetenyi, G. & Bernkop-Schnurch, A. Thiolated hyaluronic acid as versatile mucoadhesive polymer: from the chemistry behind to product developments-what are the capabilities? Polymer 10, 243 (2018).
Spearman, B. S. et al. Tunable methacrylated hyaluronic acid-based hydrogels as scaffolds for soft tissue engineering applications. J. Biomed. Mater. Res. A 108, 279–291 (2020).
Google Scholar
Lee, K. Y. & Mooney, D. J. Alginate: properties and biomedical applications. Prog. Polym. Sci. 37, 106–126 (2012).
Google Scholar
Li, Y., Meng, H., Liu, Y. & Lee, B. P. Fibrin gel as an injectable biodegradable scaffold and cell carrier for tissue engineering. Sci. World J. 2015, 685690 (2015).
Fiamingo, A. et al. Chitosan hydrogels for the regeneration of infarcted myocardium: preparation, physicochemical characterization, and biological evaluation. Biomacromolecules 17, 1662–1672 (2016).
Google Scholar
Zareei, A. et al. A lab-on-chip ultrasonic platform for real-time and nondestructive assessment of extracellular matrix stiffness. Lab Chip 20, 778–788 (2020).
Google Scholar
Khoury, L. R. & Popa, I. Chemical unfolding of protein domains induces shape change in programmed protein hydrogels. Nat. Commun. 10, 5439 (2019).
Google Scholar
Wu, D. et al. Polymers with controlled assembly and rigidity made with click-functional peptide bundles. Nature 574, 658–662 (2019).
Google Scholar
Mondal, S., Das, S. & Nandi, A. K. A review on recent advances in polymer and peptide hydrogels. Soft Matter 16, 1404–1454 (2020).
Google Scholar
Liu, C., Zhang, Q., Zhu, S., Liu, H. & Chen, J. Preparation and applications of peptide-based injectable hydrogels. RSC Adv. 9, 28299–28311 (2019).
Google Scholar
Li, F., Tang, J., Geng, J., Luo, D. & Yang, D. Polymeric DNA hydrogel: design, synthesis and applications. Prog. Polym. Sci. 98, 101163 (2019).
Google Scholar
Chen, H.-Q., Yang, W., Zuo, H., He, H.-W. & Wang, Y.-J. Recent advances of DNA hydrogels in biomedical applications. J. Anal. Test. 5, 155–164 (2021).
Wang, D., Hu, Y., Liu, P. & Luo, D. Bioresponsive DNA hydrogels: beyond the conventional stimuli responsiveness. Acc. Chem. Res. 50, 733–739 (2017).
Google Scholar
Della Sala, F. et al. Mechanical behavior of bioactive poly(ethylene glycol) diacrylate matrices for biomedical application. J. Mech. Behav. Biomed. Mater. 110, 103885 (2020).
Google Scholar
Muduli, S. et al. Stem cell culture on polyvinyl alcohol hydrogels having different elasticity and immobilized with ECM-derived oligopeptides. J. Polym. Eng. 37, 647–660 (2017).
Google Scholar
Kim, T. H. et al. Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing-thawing method to investigate stem cell differentiation behaviors. Biomaterials 40, 51–60 (2015).
Google Scholar
Sapalidis, A. et al. Fabrication of antibacterial poly (vinyl alcohol) nanocomposite films containing dendritic polymer functionalized multi-walled carbon nanotubes. Front. Mater. 5, 11 (2018).
Trappmann, B. et al. Extracellular-matrix tethering regulates stem-cell fate. Nat. Mater. 11, 642–649 (2012).
Google Scholar
Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006).
Google Scholar
Dong, L., Wang, S. J., Zhao, X. R., Zhu, Y. F. & Yu, J. K. 3D-printed poly(epsilon-caprolactone) scaffold integrated with cell-laden chitosan hydrogels for bone tissue engineering. Sci. Rep. 7, 13412 (2017).
Google Scholar
Farrukh, A., Zhao, S. & del Campo, A. Microenvironments designed to support growth and function of neuronal cells. Front. Mater. 5, 62 (2018).
Hsieh, F. Y., Lin, H. H. & Hsu, S. H. 3D bioprinting of neural stem cell-laden thermoresponsive biodegradable polyurethane hydrogel and potential in central nervous system repair. Biomaterials 71, 48–57 (2015).
Google Scholar
Lin, P., Ma, S., Wang, X. & Zhou, F. Molecularly engineered dual-crosslinked hydrogel with ultrahigh mechanical strength, toughness, and good self-recovery. Adv. Mater. 27, 2054–2059 (2015).
Google Scholar
Sun, G., Zhang, X.-Z. & Chu, C.-C. Effect of the molecular weight of polyethylene glycol (PEG) on the properties of chitosan-PEG-poly(N-isopropylacrylamide) hydrogels. J. Mater. Sci. Mater. Med. 19, 2865–2872 (2008).
Google Scholar
Wu, F., Pang, Y. & Liu, J. Swelling-strengthening hydrogels by embedding with deformable nanobarriers. Nat. Commun. 11, 4502 (2020).
Google Scholar
Van Tomme, S. R., Storm, G. & Hennink, W. E. In situ gelling hydrogels for pharmaceutical and biomedical applications. Int. J. Pharmacol. 355, 1–18 (2008).
Vigani, B. et al. Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes. Pharmaceutics 12, 859 (2020).
Google Scholar
Aufderhorst-Roberts, A. et al. Reaction rate governs the viscoelasticity and nanostructure of folded protein hydrogels. Biomacromolecules 21, 4253–4260 (2020).
Google Scholar
Nair, A. B. et al. Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections. PLoS ONE 16, e0248857 (2021).
Google Scholar
Xu, X. et al. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Sci. Transl. Med. 12, eaba8014 (2020).
Google Scholar
Tu, Y. et al. Advances in injectable self-healing biomedical hydrogels. Acta Biomater. 90, 1–20 (2019).
Google Scholar
Li, W. et al. All-natural injectable hydrogel with self-healing and antibacterial properties for wound dressing. Cellulose 27, 2637–2650 (2020).
Google Scholar
Li, C.-H. et al. A highly stretchable autonomous self-healing elastomer. Nat. Chem. 8, 619–625 (2016).
Akbari, V. et al. Effect of freeze drying on stability, thermo-responsive characteristics, and in vivo wound healing of erythropoietin-loaded trimethyl chitosan/glycerophosphate hydrogel. Res. Pharm. Sci. 13, 476–483 (2018).
Google Scholar
Simoni, R. C. et al. Effect of drying method on mechanical, thermal and water absorption properties of enzymatically crosslinked gelatin hydrogels. Acad. Bras. Cienc. 89, 745–755 (2017).
Google Scholar
Grenier, J., Duval, H., Barou, F., Lu, P. & Letourneur, D. J. A. B. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta Biomater. 94, 195–203 (2019).
Google Scholar
Haugh, M. G., Murphy, C. M. & O’Brien, F. J. Novel freeze-drying methods to produce a range of collagen–glycosaminoglycan scaffolds with tailored mean pore sizes. Tissue Eng. Part C Methods 16, 887–894 (2010).
Google Scholar
Fears, T. M. et al. Ultra-low-density silver aerogels via freeze-substitution. APL Mater. 6, 091103 (2018).
Rouhollahi, A., Ilegbusi, O., Florczyk, S., Xu, K. & Foroosh, H. Effect of mold geometry on pore size in freeze-cast chitosan-alginate scaffolds for tissue engineering. Ann. Biomed. Eng. 48, 1090–1102 (2020).
Google Scholar
Xue, J., Wu, T., Dai, Y. & Xia, Y. Electrospinning and electrospun nanofibers: methods, materials, and applications. Chem. Rev. 119, 5298–5415 (2019).
Google Scholar
Chen, X. et al. Fabrication and properties of electrospun collagen tubular scaffold crosslinked by physical and chemical treatments. Polymer 13, 755 (2021).
Google Scholar
Li, M., Guo, Y., Wei, Y., MacDiarmid, A. G. & Lelkes, P. I. Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. Biomaterials 27, 2705–2715 (2006).
Google Scholar
Agudelo-Garcia, P. A. et al. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia 13, 831–840 (2011).
Google Scholar
Bago, J. R. et al. Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma. Biomaterials 90, 116–125 (2016).
Google Scholar
Hu, X. et al. Electrospinning of polymeric nanofibers for drug delivery applications. J. Control. Release 185, 12–21 (2014).
Google Scholar
Kamsani, N. H., Haris, M. S., Pandey, M., Taher, M. & Rullah, K. Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview. Arab. J. Chem. 14, 103199 (2021).
Google Scholar
D’Arcangelo, E. & McGuigan, A. P. Micropatterning strategies to engineer controlled cell and tissue architecture in vitro. Biotechniques 58, 13–23 (2015).
Google Scholar
Martinez-Rivas, A., Gonzalez-Quijano, G. K., Proa-Coronado, S., Severac, C. & Dague, E. Methods of micropatterning and manipulation of cells for biomedical applications. Micromachines 8, 347 (2017).
Google Scholar
Hortobagyi, G. N. & Balch, C. M. Accomplishments in academic leadership. Breast Dis. Year Book Q. 20, 123 (2009).
Thery, M. Micropatterning as a tool to decipher cell morphogenesis and functions. J. Cell Sci. 123, 4201–4213 (2010).
Google Scholar
Monzo, P. et al. Mechanical confinement triggers glioma linear migration dependent on formin FHOD3. Mol. Biol. Cell 27, 1246–1261 (2016).
Google Scholar
Yue, X., Nguyen, T. D., Zellmer, V., Zhang, S. & Zorlutuna, P. Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions. Biomaterials 170, 37–48 (2018).
Google Scholar
Ge, Q. et al. 3D printing of highly stretchable hydrogel with diverse UV curable polymers. Sci. Adv. 7, eaba4261 (2021).
Google Scholar
Sun, Y. et al. 3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regeneration. Sci. Adv. 6, eaay1422 (2020).
Google Scholar
Knowlton, S., Anand, S., Shah, T. & Tasoglu, S. Bioprinting for neural tissue engineering. Trends Neurosci. 41, 31–46 (2018).
Google Scholar
Dai, X., Ma, C., Lan, Q. & Xu, T. 3D bioprinted glioma stem cells for brain tumor model and applications of drug susceptibility. Biofabrication 8, 045005 (2016).
Google Scholar
Genova, T. et al. Advances on bone substitutes through 3D bioprinting. Int. J. Mol. Sci. 21, 7012 (2020).
Google Scholar
Lee, K. H. et al. Microfluidic synthesis of pure chitosan microfibers for bio-artificial liver chip. Lab Chip 10, 1328–1334 (2010).
Google Scholar
Tumarkin, E. & Kumacheva, E. Microfluidic generation of microgels from synthetic and natural polymers. Chem. Soc. Rev. 38, 2161–2168 (2009).
Google Scholar
Akbari, S. & Pirbodaghi, T. Microfluidic encapsulation of cells in alginate particles via an improved internal gelation approach. Microfluid. Nanofluid. 16, 773–777 (2013).
Hwang, D. K., Dendukuri, D. & Doyle, P. S. Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles. Lab Chip 8, 1640–1647 (2008).
Google Scholar
Park, J. H. et al. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol. Bioeng. 106, 138–148 (2010).
Google Scholar
Cuchiara, M. P., Allen, A. C., Chen, T. M., Miller, J. S. & West, J. L. Multilayer microfluidic PEGDA hydrogels. Biomaterials 31, 5491–5497 (2010).
Google Scholar
Wei, Z., Schnellmann, R., Pruitt, H. C. & Gerecht, S. Hydrogel network dynamics regulate vascular morphogenesis. Cell Stem Cell 27, 798–812 (2020).
Google Scholar
Horne-Badovinac, S. Cell-cell and cell-matrix interactions. Mol. Biol. Cell 25, 731 (2014).
Google Scholar
Watt, F. M. & Fujiwara, H. Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb. Perspect. Biol. 3, a005124 (2011).
Google Scholar
Sage, E. H. Regulation of interactions between cells and extracellular matrix: a command performance on several stages. J. Clin. Invest. 107, 781–783 (2001).
Google Scholar
Lim, C. T., Bershadsky, A., & Sheetz, M. P. Mechanobiology. J. R. Soc. Interface 7(Suppl 3), 291–293 (2010).
Jansen, K. A. et al. A guide to mechanobiology: where biology and physics meet. Biochim. Biophys. Acta 1853, 3043–3052 (2015).
Google Scholar
Martino, F., Perestrelo, A. R., Vinarsky, V., Pagliari, S. & Forte, G. Cellular mechanotransduction: from tension to function. Front. Physiol. 9, 824 (2018).
Google Scholar
Chin, W.-C. et al. Role of surface chemistry in protein remodeling at the cell-material interface. PLoS ONE 6, e19610 (2011).
Bahlmann, L. C., Fokina, A. & Shoichet, M. S. Dynamic bioengineered hydrogels as scaffolds for advanced stem cell and organoid culture. MRS Commun. 7, 472–486 (2017).
Google Scholar
Vats, K. & Benoit, D. S. Dynamic manipulation of hydrogels to control cell behavior: a review. Tissue Eng. Part B Rev. 19, 455–469 (2013).
Google Scholar
Burdick, J. A. & Murphy, W. L. Moving from static to dynamic complexity in hydrogel design. Nat. Commun. 3, 1269 (2012).
Google Scholar
Gefen, A. & Margulies, S. S. Are in vivo and in situ brain tissues mechanically similar? J. Biomech. 37, 1339–1352 (2004).
Google Scholar
Engler, A. J. et al. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J. Cell Biol. 166, 877–887 (2004).
Google Scholar
Yeung, T. et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton 60, 24–34 (2005).
Google Scholar
d’Angelo, M. et al. The role of stiffness in cell reprogramming: a potential role for biomaterials in inducing tissue regeneration. Cells 8, 1036 (2019).
Google Scholar
da Silva, J., Lautenschläger, F., Sivaniah, E. & Guck, J. R. The cavity-to-cavity migration of leukaemic cells through 3D honey-combed hydrogels with adjustable internal dimension and stiffness. Biomaterials 31, 2201–2208 (2010).
Google Scholar
Zigon-Branc, S. et al. Impact of hydrogel stiffness on differentiation of human adipose-derived stem cell microspheroids. Tissue Eng. Part A 25, 1369–1380 (2019).
Google Scholar
Li, J. et al. Bioactive nanoparticle reinforced alginate/gelatin bioink for the maintenance of stem cell stemness. Mater. Sci. Eng. C Mater. Biol. Appl. 126, 112193 (2021).
Google Scholar
Sun, Z., Guo, S. S. & Fässler, R. Integrin-mediated mechanotransduction. J. Cell Biol. 215, 445–456 (2016).
Google Scholar
Shyy, J. Y. & Chien, S. Role of integrins in endothelial mechanosensing of shear stress. Circ. Res. 91, 769–775 (2002).
Google Scholar
Zhou, J. et al. Mechanism of focal adhesion kinase mechanosensing. PLoS Comput. Biol. 11, e1004593 (2015).
Google Scholar
Hoon, J., Tan, M. & Koh, C.-G. The regulation of cellular responses to mechanical cues by rho GTPases. Cells 5, 17 (2016).
Google Scholar
Lee, S. & Kumar, S. Actomyosin stress fiber mechanosensing in 2D and 3D. F1000Res 5, 2261 (2016).
Colombelli, J. et al. Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. J. Cell Sci. 122, 1665–1679 (2009).
Google Scholar
Trappmann, B. & Chen, C. S. How cells sense extracellular matrix stiffness: a material’s perspective. Curr. Opin. Biotechnol. 24, 948–953 (2013).
Google Scholar
Wang, J. G., Miyazu, M., Matsushita, E., Sokabe, M. & Naruse, K. Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. Biochem. Biophys. Res. Commun. 288, 356–361 (2001).
Google Scholar
Wu, J. C. et al. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration. Sci. Rep. 5, 18476 (2015).
Google Scholar
Zhao, X. & Guan, J. L. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv. Drug Deliv. Rev. 63, 610–615 (2011).
Google Scholar
Chen, B. H., Tzen, J. T., Bresnick, A. R. & Chen, H. C. Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells. J. Biol. Chem. 277, 33857–33863 (2002).
Google Scholar
Hsia, D. A. et al. Differential regulation of cell motility and invasion by FAK. J. Cell Biol. 160, 753–767 (2003).
Google Scholar
Deng, Y. et al. Reciprocal inhibition of YAP/TAZ and NF-kappaB regulates osteoarthritic cartilage degradation. Nat. Commun. 9, 4564 (2018).
Google Scholar
Du, J. et al. Extracellular matrix stiffness dictates Wnt expression through integrin pathway. Sci. Rep. 6, 20395 (2016).
Google Scholar
Park, J. S. et al. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-beta. Biomaterials 32, 3921–3930 (2011).
Google Scholar
Shih, Y. R., Tseng, K. F., Lai, H. Y., Lin, C. H. & Lee, O. K. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J. Bone Miner. Res. 26, 730–738 (2011).
Google Scholar
Adapala, R. K. et al. TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J. Mol. Cell Cardiol. 54, 45–52 (2013).
Google Scholar
Liu, F. et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, L344–357 (2015).
Google Scholar
Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179–183 (2011).
Google Scholar
Nardone, G. et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat. Commun. 8, 15321 (2017).
Google Scholar
Pan, J. X. et al. YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating beta-catenin signaling. Bone Res. 6, 18 (2018).
Google Scholar
Nukuda, A. et al. Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression. Oncogenesis 4, e165 (2015).
Google Scholar
Rys, J. P. et al. Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension. eLife 4, e09300 (2015).
Google Scholar
Du, J. et al. Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc. Natl Acad. Sci. USA 108, 9466–9471 (2011).
Google Scholar
Sanz-Ramos, P., Mora, G., Ripalda, P., Vicente-Pascual, M. & Izal-Azcarate, I. Identification of signalling pathways triggered by changes in the mechanical environment in rat chondrocytes. Osteoarthr. Cartil. 20, 931–939 (2012).
Google Scholar
Yang, H. et al. Materials stiffness-dependent redox metabolic reprogramming of mesenchymal stem cells for secretome-based therapeutic angiogenesis. Adv. Healthc. Mater. 8, 1900929 (2019).
Google Scholar
Sung, K. E. et al. Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. PLoS ONE 8, e76373 (2013).
Google Scholar
Imamura, Y. et al. Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer. Oncol. Rep. 33, 1837–1843 (2015).
Google Scholar
Cao, H. et al. Mechanoregulation of cancer-associated fibroblast phenotype in three-dimensional interpenetrating hydrogel networks. Langmuir 35, 7487–7495 (2019).
Google Scholar
Tay, C. Y. et al. Reality check for nanomaterial-mediated therapy with 3D biomimetic culture systems. Adv. Funct. Mater. 26, 4046–4065 (2016).
Google Scholar
Li, Q., Barret, D. G., Messersmith, P. B. & Holten-Andersen, N. Controlling hydrogel mechanics via bio-inspired polymer-nanoparticle bond dynamics. ACS Nano 10, 1317–1324 (2016).
Google Scholar
Lim, D. G., Kang, E. & Jeong, S. H. pH-dependent nanodiamonds enhance the mechanical properties of 3D-printed hyaluronic acid nanocomposite hydrogels. J. Nanobiotechnol. 18, 88 (2020).
Google Scholar
Arno, M. C. et al. Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties. Nat. Commun. 11, 1420 (2020).
Google Scholar
Hua, M. et al. Strong tough hydrogels via the synergy of freeze-casting and salting out. Nature 590, 594–599 (2021).
Google Scholar
Du, F. et al. Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding. Nat. Commun. 11, 4896 (2020).
Google Scholar
Li, L. & Jiang, J. Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms. Front. Med. 5, 33–39 (2011).
Google Scholar
Petrie, R. J., Koo, H. & Yamada, K. M. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science 345, 1062–1065 (2014).
Google Scholar
Hung, W. C. et al. Distinct signaling mechanisms regulate migration in unconfined versus confined spaces. J. Cell Biol. 202, 807–824 (2013).
Google Scholar
Alexander, S., Koehl, G. E., Hirschberg, M., Geissler, E. K. & Friedl, P. Dynamic imaging of cancer growth and invasion: A modified skin-fold chamber model. Histochem. Cell Biol. 130, 1147–1154 (2008).
Google Scholar
Friedl, P. & Alexander, S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147, 992–1009 (2011).
Google Scholar
Alexander, S., Weigelin, B., Winkler, F. & Friedl, P. Preclinical intravital microscopy of the tumour-stroma interface: Invasion, metastasis, and therapy response. Curr. Opin. Cell Biol. 25, 659–671 (2013).
Google Scholar
Weigelin, B., Bakker, G. J. & Friedl, P. Intravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics. Intravital 1, 32–43 (2012).
Google Scholar
Raman, P. S., Paul, C. D., Stroka, K. M. & Konstantopoulos, K. Probing cell traction forces in confined microenvironments. Lab Chip 13, 4599–4607 (2013).
Google Scholar
Doolin, M. T. & Stroka, K. M. Physical confinement alters cytoskeletal contributions towards human mesenchymal stem cell migration. Cytoskeleton 75, 103–117 (2018).
Google Scholar
Desai, S. P., Bhatia, S. N., Toner, M. & Irimia, D. Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophys. J. 104, 2077–2088 (2013).
Google Scholar
Wang, K. et al. Nanotopographical modulation of cell function through nuclear deformation. ACS Appl. Mater. Interfaces 8, 5082–5092 (2016).
Google Scholar
Khatau, S. B. et al. The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Sci. Rep. 2, 488 (2012).
Google Scholar
Petrie, R. J. & Yamada, K. M. Fibroblasts lead the way: A unified view of 3D cell motility. Trends Cell Biol. 25, 666–674 (2015).
Google Scholar
Nasrollahi, S. & Pathak, A. Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices. Sci. Rep. 6, 18831 (2016).
Google Scholar
Lo, Y. P. et al. Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells. Sci. Rep. 6, 21253 (2016).
Google Scholar
Fraley, S. I. et al. A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat. Cell Biol. 12, 598–604 (2010).
Google Scholar
Kim, J. et al. Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. Nat. Commun. 6, 6781 (2015).
Google Scholar
Elosegui-Artola, A. et al. Force Triggers YAP nuclear entry by regulating transport across nuclear pores. Cell 171, 1397–1410 (2017).
Google Scholar
Mierke, C. T. et al. Breakdown of the endothelial barrier function in tumor cell transmigration. Biophys. J. 94, 2832–2846 (2008).
Google Scholar
Fogh, B. S., Multhaupt, H. A. & Couchman, J. R. Protein kinase C, focal adhesions and the regulation of cell migration. J. Histochem. Cytochem. 62, 172–184 (2014).
Google Scholar
Fu, Y., Chin, L. K., Bourouina, T., Liu, A. Q. & VanDongen, A. M. Nuclear deformation during breast cancer cell transmigration. Lab Chip 12, 3774–3778 (2012).
Google Scholar
Koch, B. et al. Confinement and deformation of single cells and their nuclei inside size-adapted microtubes. Adv. Healthc. Mater. 3, 1753–1758 (2014).
Google Scholar
Xi, W. et al. Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies. Nano Lett. 14, 4197–4204 (2014).
Google Scholar
Irianto, J. et al. Nuclear constriction segregates mobile nuclear proteins away from chromatin. Mol. Biol. Cell 27, 4011–4020 (2016).
Google Scholar
Makhija, E., Jokhun, D. S. & Shivashankar, G. V. Nuclear deformability and telomere dynamics are regulated by cell geometric constraints. Proc. Natl Acad. Sci. USA 113, E32–E40 (2016).
Google Scholar
Bronshtein, I. et al. Loss of lamin A function increases chromatin dynamics in the nuclear interior. Nat. Commun. 6, 8044 (2015).
Google Scholar
McAndrews, K. M., Kim, M. J., Lam, T. Y., McGrail, D. J. & Dawson, M. R. Architectural and mechanical cues direct mesenchymal stem cell interactions with crosslinked gelatin scaffolds. Tissue Eng. Part A 20, 3252–3260 (2014).
Google Scholar
Huang, B. et al. The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition. Sci. Rep. 4, 6449 (2014).
Google Scholar
Zanotelli, M. R. et al. Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making. Nat. Commun. 10, 4185 (2019).
Google Scholar
Mosier, J. A., Wu, Y. & Reinhart-King, C. A. Recent advances in understanding the role of metabolic heterogeneities in cell migration. Fac. Rev. 10, 8 (2021).
Google Scholar
Huang, D. et al. Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction. Acta Biomater. 97, 74–92 (2019).
Google Scholar
Maccabi, A. et al. Quantitative characterization of viscoelastic behavior in tissue-mimicking phantoms and ex vivo animal tissues. PLoS ONE 13, e0191919 (2018).
Google Scholar
Larin, K. V., Sampson, D. D., Greenleaf, J. F. & Alizad, A. Introduction. Optical Elastography Tissue Biomech. 8946, 894601 (2017).
Li, L., Eyckmans, J. & Chen, C. S. Designer biomaterials for mechanobiology. Nat. Mater. 16, 1164–1168 (2017).
Google Scholar
Dey, K., Agnelli, S. & Sartore, L. Dynamic freedom: substrate stress relaxation stimulates cell responses. Biomater. Sci. 7, 836–842 (2019).
Google Scholar
Cameron, A. R., Frith, J. E., Gomez, G. A., Yap, A. S. & Cooper-White, J. J. The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells. Biomaterials 35, 1857–1868 (2014).
Google Scholar
Cho, J., Heuzey, M.-C., Bégin, A. & Carreau, P. J. Viscoelastic properties of chitosan solutions: Effect of concentration and ionic strength. J. Food Eng. 74, 500–515 (2006).
Google Scholar
Charbonier, F., Indana, D. & Chaudhuri, O. Tuning viscoelasticity in alginate hydrogels for 3D cell culture studies. Curr. Protoc. 1, e124 (2021).
Google Scholar
Nakka, J. S., Jansen, K. M. B. & Ernst, L. J. Effect of chain flexibility in the network structure on the viscoelasticity of epoxy thermosets. J. Polym. Res. 18, 1879–1888 (2011).
Google Scholar
Vunjak-Novakovic, G. Dynamic hydrogels for investigating vascularization. Cell Stem Cell 27, 697–698 (2020).
Google Scholar
Dwivedi, N., Das, S., Bellare, J. & Majumder, A. Viscoelastic substrate decouples cellular traction force from other related phenotypes. Biochem. Biophys. Res. Commun. 543, 38–44 (2021).
Google Scholar
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J. & Shenoy, V. B. Effects of extracellular matrix viscoelasticity on cellular behaviour. Nature 584, 535–546 (2020).
Google Scholar
Wisdom, K. M. et al. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat. Commun. 9, 4144 (2018).
Google Scholar
Lee, H. P., Gu, L., Mooney, D. J., Levenston, M. E. & Chaudhuri, O. Mechanical confinement regulates cartilage matrix formation by chondrocytes. Nat. Mater. 16, 1243–1251 (2017).
Google Scholar
Fischer, M., Rikeit, P., Knaus, P. & Coirault, C. YAP-mediated mechanotransduction in skeletal muscle. Front. Physiol. 7, 41 (2016).
Google Scholar
Schwartz, C. et al. Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1. Sci. Rep. 7, 1253 (2017).
Google Scholar
Theocharis, A. D., Manou, D. & Karamanos, N. K. The extracellular matrix as a multitasking player in disease. FEBS J. 286, 2830–2869 (2019).
Google Scholar
Xue, M. & Jackson, C. J. Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv. Wound Care 4, 119–136 (2015).
Gumpangseth, T., Lekawanvijit, S. & Mahakkanukrauh, P. Histological assessment of the human heart valves and its relationship with age. Anat. Cell Biol. 53, 261–271 (2020).
Google Scholar
McMurtrey, R. J. Patterned and functionalized nanofiber scaffolds in three-dimensional hydrogel constructs enhance neurite outgrowth and directional control. J. Neural Eng. 11, 066009 (2014).
Google Scholar
Lee, S., Kim, H. S. & Yoo, H. S. Electrospun nanofibrils embedded hydrogel composites for cell cultivation in a biomimetic environment. RSC Adv. 7, 54246–54253 (2017).
Google Scholar
Kievit, F. M. et al. Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv. Healthc. Mater. 2, 1651–1659 (2013).
Google Scholar
Meehan, S. & Nain, A. S. Role of suspended fiber structural stiffness and curvature on single-cell migration, nucleus shape, and focal-adhesion-cluster length. Biophys. J. 107, 2604–2611 (2014).
Google Scholar
English, A. et al. Substrate topography: a valuable in vitro tool, but a clinical red herring for in vivo tenogenesis. Acta Biomater. 27, 3–12 (2015).
Google Scholar
Chaurey, V. et al. Nanofiber size-dependent sensitivity of fibroblast directionality to the methodology for scaffold alignment. Acta Biomater. 8, 3982–3990 (2012).
Google Scholar
Noriega, S. E., Hasanova, G. I., Schneider, M. J., Larsen, G. F. & Subramanian, A. Effect of fiber diameter on the spreading, proliferation and differentiation of chondrocytes on electrospun chitosan matrices. Cells Tissues Organs 195, 207–221 (2012).
Google Scholar
Watari, S. et al. Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves. Biomaterials 33, 128–136 (2012).
Google Scholar
Abbasi, N. et al. Influence of oriented nanofibrous PCL scaffolds on quantitative gene expression during neural differentiation of mouse embryonic stem cells. J. Biomed. Mater. Res. A 104, 155–164 (2016).
Google Scholar
Wang, J. et al. The effects of electrospun TSF nanofiber diameter and alignment on neuronal differentiation of human embryonic stem cells. J. Biomed. Mater. Res. A 100, 632–645 (2012).
Google Scholar
Saino, E. et al. Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines. Biomacromolecules 12, 1900–1911 (2011).
Google Scholar
Schoenenberger, A. D. et al. Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo. Biomaterials 249, 120034 (2020).
Google Scholar
Yu, C., Xing, M., Wang, L. & Guan, G. Effects of aligned electrospun fibers with different diameters on hemocompatibility, cell behaviors and inflammation in vitro. Biomed. Mater. 15, 035005 (2020).
Google Scholar
El Khatib, M. et al. Electrospun PLGA fiber diameter and alignment of tendon biomimetic fleece potentiate tenogenic differentiation and immunomodulatory function of amniotic epithelial stem cells. Cells 9, 1207 (2020).
Google Scholar
Lee, C. H. et al. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26, 1261–1270 (2005).
Google Scholar
Heath, D. E., Lannutti, J. J. & Cooper, S. L. Electrospun scaffold topography affects endothelial cell proliferation, metabolic activity, and morphology. J. Biomed. Mater. Res. A 94, 1195–1204 (2010).
Google Scholar
Subramony, S. D. et al. The guidance of stem cell differentiation by substrate alignment and mechanical stimulation. Biomaterials 34, 1942–1953 (2013).
Google Scholar
Yan, J. et al. Effect of fiber alignment in electrospun scaffolds on keratocytes and corneal epithelial cells behavior. J. Biomed. Mater. Res. A 100, 527–535 (2012).
Google Scholar
Jablonska-Trypuc, A., Matejczyk, M. & Rosochacki, S. Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs. J. Enzym. Inhib. Med. Chem. 31, 177–183 (2016).
Google Scholar
Kessenbrock, K., Plaks, V. & Werb, Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141, 52–67 (2010).
Google Scholar
Imaninezhad, M., Hill, L., Kolar, G., Vogt, K. & Zustiak, S. P. Templated macroporous polyethylene glycol hydrogels for spheroid and aggregate cell culture. Bioconjug. Chem. 30, 34–46 (2019).
Google Scholar
Feng, Q., Zhu, M., Wei, K. & Bian, L. Cell-mediated degradation regulates human mesenchymal stem cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS ONE 9, e99587 (2014).
Google Scholar
Pandya, P., Orgaz, J. L. & Sanz-Moreno, V. Modes of invasion during tumour dissemination. Mol. Oncol. 11, 5–27 (2017).
Google Scholar
Das, A., Monteiro, M., Barai, A., Kumar, S. & Sen, S. MMP proteolytic activity regulates cancer invasiveness by modulating integrins. Sci. Rep. 7, 14219 (2017).
Google Scholar
Pelaez, R. et al. Beta3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells. PLoS ONE 12, e0181579 (2017).
Google Scholar
Zhao, L. et al. LOX inhibition downregulates MMP-2 and MMP-9 in gastric cancer tissues and cells. J. Cancer 10, 6481–6490 (2019).
Google Scholar
Jiang, D. & Lim, S. Y. Influence of immune myeloid cells on the extracellular matrix during cancer metastasis. Cancer Microenviron. 9, 45–61 (2016).
Google Scholar
Carey, S. P. et al. Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks. Am. J. Physiol. Cell Physiol. 308, C436–447 (2015).
Google Scholar
Tang, Y. et al. MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis. Dev. Cell 25, 402–416 (2013).
Google Scholar
Taubenberger, A. V. et al. 3D Microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK. Adv. Biosyst. 3, e1900128 (2019).
Google Scholar
Khetan, S. et al. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat. Mater. 12, 458–465 (2013).
Google Scholar
Gibson, N. J. Cell adhesion molecules in context: CAM function depends on the neighborhood. Cell Adh. Migr. 5, 48–51 (2011).
Google Scholar
Matsuo, M., Sakurai, H., Ueno, Y., Ohtani, O. & Saiki, I. Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. Cancer Sci. 97, 155–162 (2006).
Google Scholar
Wang, C. Z., Su, H. W., Hsu, Y. C., Shen, M. R. & Tang, M. J. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Mol. Biol. Cell 17, 2839–2852 (2006).
Google Scholar
Santos, A. R. et al. beta1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. PLoS ONE 7, e48332 (2012).
Google Scholar
Chen, J. W. et al. Controlling the surface chemistry of a hydrogel for spatially defined cell adhesion. ACS Appl. Mater. Interfaces 11, 15411–15416 (2019).
Google Scholar
Mager, M. D., LaPointe, V. & Stevens, M. M. Exploring and exploiting chemistry at the cell surface. Nat. Chem. 3, 582–589 (2011).
Google Scholar
Yu, T.-T. et al. Influence of surface chemistry on adhesion and osteo/odontogenic differentiation of dental pulp stem cells. ACS Biomater. Sci. Eng. 3, 1119–1128 (2017).
Google Scholar
Rago, A. P., Napolitano, A. P., Dean, D. M., Chai, P. R. & Morgan, J. R. Miniaturization of an Anoikis assay using non-adhesive micromolded hydrogels. Cytotechnology 56, 81–90 (2008).
Google Scholar
Hunt, N. C. et al. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomater. 49, 329–343 (2017).
Google Scholar
Lin, C. C., Metters, A. T. & Anseth, K. S. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials 30, 4907–4914 (2009).
Google Scholar
Pinkse, G. G., Jiawan-Lalai, R., Bruijn, J. A. & de Heer, E. RGD peptides confer survival to hepatocytes via the beta1-integrin-ILK-pAkt pathway. J. Hepatol. 42, 87–93 (2005).
Google Scholar
Balasubramanian, S. & Kuppuswamy, D. RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells. J. Biol. Chem. 278, 42214–42224 (2003).
Google Scholar
Zhang, L., Xiong, N., Liu, Y. & Gan, L. Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells. Regen. Biomater. 8, rbaa057 (2021).
Google Scholar
Ekerdt, B. L., Segalman, R. A. & Schaffer, D. V. Spatial organization of cell-adhesive ligands for advanced cell culture. Biotechnol. J. 8, 1411–1423 (2013).
Google Scholar
Nemec, S. & Kilian, K. A. Materials control of the epigenetics underlying cell plasticity. Nat. Rev. Mater. 6, 69–83 (2020).
Maheshwari, G., Brown, G., Lauffenburger, D. A., Wells, A. & Griffith, L. G. Cell adhesion and motility depend on nanoscale RGD clustering. J. Cell Sci. 113, 1677–1686 (2000).
Google Scholar
Lewis, D. M., Blatchley, M. R., Park, K. M. & Gerecht, S. O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo. Nat. Protoc. 12, 1620–1638 (2017).
Google Scholar
Park, K. M. & Gerecht, S. Hypoxia-inducible hydrogels. Nat. Commun. 5, 4075 (2014).
Google Scholar
Yoshitomi, T., Zheng, H. & Yoshimoto, K. Investigations of chirality effects on undifferentiated state of mesenchymal stem cells using soft nanofibrous oligopeptide hydrogels. Anal. Sci. 37, 539–543 (2021).
Google Scholar
Griffin, D. R. et al. Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. Nat. Mater. 20, 560–569 (2021).
Google Scholar
Liu, G. F., Zhang, D. & Feng, C. L. Control of three-dimensional cell adhesion by the chirality of nanofibers in hydrogels. Angew. Chem. Int. Ed. 53, 7789–7793 (2014).
Google Scholar
Grim, J. C., Marozas, I. A. & Anseth, K. S. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels. J. Control. Release 219, 95–106 (2015).
Google Scholar
Browne, S. et al. TGF-beta1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PLoS ONE 13, e0194679 (2018).
Google Scholar
Reid, B. et al. Enhanced tissue production through redox control in stem cell-laden hydrogels. Tissue Eng. Part A 19, 2014–2023 (2013).
Google Scholar
Cai, W. et al. Influence of supramolecular chiral hydrogel on cellular behavior of endothelial cells under high-glucose-induced injury. J. Shanghai Jiaotong Univ. (Sci.) 26, 17–24 (2021).
Wei, Z. et al. Self-healing gels based on constitutional dynamic chemistry and their potential applications. Chem. Soc. Rev. 43, 8114–8131 (2014).
Google Scholar
Hsieh, F.-Y., Tao, L., Wei, Y. & Hsu, S.-H. A novel biodegradable self-healing hydrogel to induce blood capillary formation. NPG Asia Mater. 9, e363 (2017).
Google Scholar
Zhou, L. et al. Soft conducting polymer hydrogels cross-linked and doped by tannic acid for spinal cord injury repair. ACS Nano 12, 10957–10967 (2018).
Google Scholar
Zou, L. et al. Current approaches of photothermal therapy in treating cancer metastasis with nanotherapeutics. Theranostics 6, 762–772 (2016).
Google Scholar
Luo, Y. et al. 3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair. Acta Biomater. 92, 37–47 (2019).
Google Scholar
Mohamed, M. A. et al. Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology. Prog. Polym. Sci. 98, 101147 (2019).
Google Scholar
Wu, Z. L. et al. Three-dimensional shape transformations of hydrogel sheets induced by small-scale modulation of internal stresses. Nat. Commun. 4, 1586 (2013).
Google Scholar
Sood, N., Bhardwaj, A., Mehta, S. & Mehta, A. Stimuli-responsive hydrogels in drug delivery and tissue engineering. Drug Deliv. 23, 758–780 (2016).
Google Scholar
Cimmino, C., Rossano, L., Netti, P. A. & Ventre, M. Spatio-temporal control of cell adhesion: toward programmable platforms to manipulate cell functions and fate. Front. Bioeng. Biotechnol. 6, 190 (2018).
Google Scholar
Kamimura, M., Sugawara, M., Yamamoto, S., Yamaguchi, K. & Nakanishi, J. Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration. Biomater. Sci. 4, 933–937 (2016).
Google Scholar
Doyle, A. D., Carvajal, N., Jin, A., Matsumoto, K. & Yamada, K. M. Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. Nat. Commun. 6, 8720 (2015).
Google Scholar
Wu, X. et al. Reversible hydrogels with tunable mechanical properties for optically controlling cell migration. Nano Res. 11, 5556–5565 (2018).
Google Scholar
Tong, Z. et al. Adaptable hydrogel with reversible linkages for regenerative medicine: dynamic mechanical microenvironment for cells. Bioact. Mater. 6, 1375–1387 (2021).
Google Scholar
Zhang, J. et al. Dynamic mechanics-modulated hydrogels to regulate the differentiation of stem-cell spheroids in soft microniches and modeling of the nonlinear behavior. Small 15, e1901920 (2019).
Google Scholar
Liu, H. Y., Korc, M. & Lin, C. C. Biomimetic and enzyme-responsive dynamic hydrogels for studying cell-matrix interactions in pancreatic ductal adenocarcinoma. Biomaterials 160, 24–36 (2018).
Google Scholar
Desseaux, S. & Klok, H. A. Temperature-controlled masking/unmasking of cell-adhesive cues with poly(ethylene glycol) methacrylate based brushes. Biomacromolecules 15, 3859–3865 (2014).
Google Scholar
Wegner, S. V., Senturk, O. I. & Spatz, J. P. Photocleavable linker for the patterning of bioactive molecules. Sci. Rep. 5, 18309 (2015).
Google Scholar
Hammer, J. A. & West, J. L. Dynamic ligand presentation in biomaterials. Bioconjug. Chem. 29, 2140–2149 (2018).
Google Scholar
Wang, R., Fu, L., Liu, J. & Li, H. Decorating protein hydrogels reversibly enables dynamic presentation and release of functional protein ligands on protein hydrogels. Chem. Commun. 55, 12703–12706 (2019).
Google Scholar
DeForest, C. A. & Tirrell, D. A. A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels. Nat. Mater. 14, 523–531 (2015).
Google Scholar
Stowers, R. S., Allen, S. C. & Suggs, L. J. Dynamic phototuning of 3D hydrogel stiffness. Proc. Natl Acad. Sci. USA 112, 1953–1958 (2015).
Google Scholar
LeValley, P. J. & Kloxin, A. M. Chemical approaches to dynamically modulate the properties of synthetic matrices. ACS Macro Lett. 8, 7–16 (2019).
Google Scholar
Gillette, B. M., Jensen, J. A., Wang, M., Tchao, J. & Sia, S. K. Dynamic hydrogels: switching of 3D microenvironments using two-component naturally derived extracellular matrices. Adv. Mater. 22, 686–691 (2010).
Google Scholar
Branco da Cunha, C. et al. Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology. Biomaterials 35, 8927–8936 (2014).
Google Scholar
Cao, H., Cheng, H. S., Wang, J. K., Tan, N. S. & Tay, C. Y. A 3D physio-mimetic interpenetrating network-based platform to decode the pro and anti-tumorigenic properties of cancer-associated fibroblasts. Acta Biomater. 132, 448–460 (2021).
Google Scholar
Ravi, M., Paramesh, V., Kaviya, S. R., Anuradha, E. & Solomon, F. D. 3D cell culture systems: advantages and applications. J. Cell Physiol. 230, 16–26 (2015).
Google Scholar
Zhang, K. et al. Quantum yield-engineered biocompatible probes illuminate lung tumor based on viscosity confinement-mediated antiaggregation. Adv. Funct. Mater. 29, 1905124 (2019).
Google Scholar
Monteiro, M. V., Gaspar, V. M., Ferreira, L. P. & Mano, J. F. Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug response. Biomater. Sci. 8, 1855–1864 (2020).
Google Scholar
Asghar, W. et al. Engineering cancer microenvironments for in vitro 3-D tumor models. Mater. Today 18, 539–553 (2015).
Google Scholar
Langhans, S. A. Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Front. Pharmacol. 9, 6 (2018).
Google Scholar
Suzuka, J. et al. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nat. Biomed. Eng. 5, 914–925 (2021).
Google Scholar
Hu, X. et al. On-chip hydrogel arrays individually encapsulating acoustic formed multicellular aggregates for high throughput drug testing. Lab Chip 20, 2228–2236 (2020).
Google Scholar
Papadimitriou, C. et al. 3D culture method for alzheimer’s disease modeling reveals interleukin-4 rescues Abeta42-induced loss of human neural stem cell plasticity. Dev. Cell 46, 85–101 (2018).
Google Scholar
Crunkhorn, S. Hydrogel fights infection and inflammation. Nat. Rev. Drug Discov. 19, 92 (2020).
Google Scholar
Zhu, D. et al. Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. Nat. Commun. 12, 1412 (2021).
Google Scholar
Smith, D. J. et al. A multiphase transitioning peptide hydrogel for suturing ultrasmall vessels. Nat. Nanotechnol. 11, 95–102 (2016).
Google Scholar
Zhang, J. et al. A pulsatile release platform based on photo-induced imine-cross-linking hydrogel promotes scarless wound healing. Nat. Commun. 12, 1670 (2021).
Google Scholar
Gao, L. et al. A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing. NPG Asia Mater. 11, 66 (2019).
Google Scholar
Tang, X. et al. Stable antibacterial polysaccharide-based hydrogels as tissue adhesives for wound healing. RSC Adv. 10, 17280–17287 (2020).
Google Scholar
Cao, H. et al. Fish collagen-based scaffold containing PLGA microspheres for controlled growth factor delivery in skin tissue engineering. Colloids Surf. B Biointerfaces 136, 1098–1106 (2015).
Google Scholar
Chen, H. et al. An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing. Carbohydr. Polym. 201, 522–531 (2018).
Google Scholar
Moon, J. J. et al. Biomimetic hydrogels with pro-angiogenic properties. Biomaterials 31, 3840–3847 (2010).
Google Scholar
Debats, I. B. et al. Role of arginine in superficial wound healing in man. Nitric Oxide 21, 175–183 (2009).
Google Scholar
Xiao, B., Wan, Y., Zhao, M., Liu, Y. & Zhang, S. Preparation and characterization of antimicrobial chitosan-N-arginine with different degrees of substitution. Carbohydr. Polym. 83, 144–150 (2011).
Google Scholar
Wu, D. Q. et al. Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study. Acta Biomater. 65, 305–316 (2018).
Google Scholar
He, M., Potuck, A., Zhang, Y. & Chu, C. C. Arginine-based polyester amide/polysaccharide hydrogels and their biological response. Acta Biomater. 10, 2482–2494 (2014).
Google Scholar
Li, R. et al. Heparin-poloxamer thermosensitive hydrogel loaded with bFGF and NGF enhances peripheral nerve regeneration in diabetic rats. Biomaterials 168, 24–37 (2018).
Google Scholar
Li, R. et al. Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration. Acta Pharmacol. Sin. 41, 1289–1300 (2020).
Google Scholar
Aoki, K., Alles, N., Soysa, N. & Ohya, K. Peptide-based delivery to bone. Adv. Drug Deliv. Rev. 64, 1220–1238 (2012).
Google Scholar
Arinzeh, T. L., Tran, T., McAlary, J. & Daculsi, G. A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation. Biomaterials 26, 3631–3638 (2005).
Google Scholar
Madl, C. M., Mehta, M., Duda, G. N., Heilshorn, S. C. & Mooney, D. J. Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells. Biomacromolecules 15, 445–455 (2014).
Google Scholar
Zhang, X. et al. Immobilization of BMP-2-derived peptides on 3D-printed porous scaffolds for enhanced osteogenesis. Biomed. Mater. 15, 015002 (2019).
Google Scholar
Luan, C., Liu, P., Chen, R. & Chen, B. Hydrogel based 3D carriers in the application of stem cell therapy by direct injection. Nanotechnol. Rev. 6, 435–448 (2017).
Google Scholar
Youngblood, R. L., Truong, N. F., Segura, T. & Shea, L. D. It’s all in the delivery: designing hydrogels for cell and non-viral gene therapies. Mol. Ther. 26, 2087–2106 (2018).
Google Scholar
An, G. et al. Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1 alpha-expressing stem cells. Nat. Commun. 11, 2687 (2020).
Google Scholar
Murphy, M. P. et al. Articular cartilage regeneration by activated skeletal stem cells. Nat. Med. 26, 1583–1592 (2020).
Google Scholar
Goldfracht, I. et al. Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes. Nat. Commun. 11, 75 (2020).
Google Scholar
Chu, D. T. et al. Recent progress of stem cell therapy in cancer treatment: molecular mechanisms and potential applications. Cells 9, 563 (2020).
Google Scholar
Squillaro, T., Peluso, G. & Galderisi, U. Clinical trials with mesenchymal stem cells: an update. Cell Transpl. 25, 829–848 (2016).
Ballios, B. G. et al. A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation. Stem Cell Rep. 4, 1031–1045 (2015).
Google Scholar
Xu, B. et al. Advances of stem cell-laden hydrogels with biomimetic microenvironment for osteochondral repair. Front. Bioeng. Biotechnol. 8, 247 (2020).
Google Scholar
Daneshmandi, L. et al. Emergence of the stem cell secretome in regenerative engineering. Trends Biotechnol. 38, 1373–1384 (2020).
Google Scholar
Yang, H., Nguyen, K. T., Leong, D. T., Tan, N. S. & Tay, C. Y. Soft material approach to induce oxidative stress in mesenchymal stem cells for functional tissue repair. ACS Appl. Mater. Interfaces 8, 26591–26599 (2016).
Google Scholar
Nolan, C. J., Damm, P. & Prentki, M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 378, 169–181 (2011).
Google Scholar
Atkinson, M. A., Eisenbarth, G. S. & Michels, A. W. Type 1 diabetes. Lancet 383, 69–82 (2014).
Google Scholar
Shapiro, A. M., Pokrywczynska, M. & Ricordi, C. Clinical pancreatic islet transplantation. Nat. Rev. Endocrinol. 13, 268–277 (2017).
Google Scholar
Enns, L. & Ladiges, W. Mitochondrial redox signaling and cancer invasiveness. J. Bioenerg. Biomembr. 44, 635–638 (2012).
Google Scholar
Nyitray, C. E., Chavez, M. G. & Desai, T. A. Compliant 3D microenvironment improves beta-cell cluster insulin expression through mechanosensing and beta-catenin signaling. Tissue Eng. Part A 20, 1888–1895 (2014).
Google Scholar
Cui, J. et al. Multicellular co-culture in three-dimensional gelatin methacryloyl hydrogels for liver tissue engineering. Molecules 24, 1762 (2019).
Google Scholar
Kim, S., Park, M. R., Choi, C., Kim, J. B. & Cha, C. Synergistic control of mechanics and microarchitecture of 3D bioactive hydrogel platform to promote the regenerative potential of engineered hepatic tissue. Biomaterials 270, 120688 (2021).
Google Scholar
Deegan, D. B., Zimmerman, C., Skardal, A., Atala, A. & Shupe, T. D. Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology. J. Mech. Behav. Biomed. Mater. 55, 87–103 (2015).
Google Scholar
Liu, J. et al. Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting. Nat. Commun. 12, 3402 (2021).
Google Scholar
Campbell, K. T., Stilhano, R. S. & Silva, E. A. Enzymatically degradable alginate hydrogel systems to deliver endothelial progenitor cells for potential revasculature applications. Biomaterials 179, 109–121 (2018).
Google Scholar
Nilforoushzadeh, M. A. et al. Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin-collagen hydrogel: a clinical study for diabetic wound healing. J. Tissue Eng. Regen. Med. 14, 424–440 (2020).
Google Scholar
Traverse, J. H. et al. First-in-man study of a cardiac extracellular matrix hydrogel in early and late myocardial infarction patients. JACC Basic Transl. Sci. 4, 659–669 (2019).
Google Scholar
Guerra, A. D., Yeung, O. W. H., Qi, X., Kao, W. J. & Man, K. The anti-tumor effects of M1 macrophage-loaded poly (ethylene glycol) and gelatin-based hydrogels on hepatocellular carcinoma. Theranostics 7, 3732–3744 (2017).
Google Scholar
Dai, X. et al. Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel. Theranostics 10, 3049–3063 (2020).
Google Scholar
Hu, Q. et al. Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets. Nat. Biomed. Eng. 5, 1038–1047 (2021).
Google Scholar
Wang, K. et al. GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision. Nat. Cancer 1, 990–997 (2020).
Google Scholar
Huang, Z., He, X., Lu, X., Yan, W. & Ji, Z. Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel. Int. J. Nanomed. 13, 7623–7631 (2018).
Google Scholar
Zhang, K. et al. Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence. Nat. Commun. 10, 5380 (2019).
Google Scholar
Gupta, M. K., Martin, J. R., Dollinger, B. R., Hattaway, M. E. & Duvall, C. L. Thermogelling, ABC triblock copolymer platform for resorbable hydrogels with tunable, degradation-mediated drug release. Adv. Funct. Mater. 27, 1704107 (2017).
Google Scholar
Ye, D. et al. Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction. Nat. Protoc. 15, 2163–2185 (2020).
Google Scholar
Lv, S.-W. et al. Near-infrared light-responsive hydrogel for specific recognition and photothermal site-release of circulating tumor cells. ACS Nano 10, 6201–6210 (2016).
Google Scholar
Chen, M. et al. Injectable anti-inflammatory nanofiber hydrogel to achieve systemic immunotherapy post local administration. Nano Lett. 20, 6763–6773 (2020).
Google Scholar
Zhang, J. et al. Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection. Nat. Nanotechnol. 16, 538–548 (2021).
Google Scholar
Ding, F. et al. Polydopamine-coated nucleic acid nanogel for siRNA-mediated low-temperature photothermal therapy. Biomaterials 245, 119976 (2020).
Google Scholar
Martin, S. J., Henry, C. M. & Cullen, S. P. A perspective on mammalian caspases as positive and negative regulators of inflammation. Mol. Cell 46, 387–397 (2012).
Google Scholar
Xing, R. et al. An injectable self-assembling collagen-gold hybrid hydrogel for combinatorial antitumor photothermal/photodynamic therapy. Adv. Mater. 28, 3669–3676 (2016).
Google Scholar
Jin, R. et al. Hollow gold nanoshells-incorporated injectable genetically engineered hydrogel for sustained chemo-photothermal therapy of tumor. J. Nanobiotechnol. 17, 99 (2019).
Christen, M. O. & Vercesi, F. Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin. Cosmet. Investig. Dermatol. 13, 31–48 (2020).
Google Scholar
Sontyana, A. G., Mathew, A. P., Cho, K. H., Uthaman, S. & Park, I. K. Biopolymeric in situ hydrogels for tissue engineering and bioimaging applications. Tissue Eng. Regen. Med. 15, 575–590 (2018).
Google Scholar
Ma, Y. et al. Bioinspired high-power-density strong contractile hydrogel by programmable elastic recoil. Sci. Adv. 6, eabd2520 (2020).
Google Scholar
Zhu, Q. L. et al. Light-steered locomotion of muscle-like hydrogel by self-coordinated shape change and friction modulation. Nat. Commun. 11, 5166 (2020).
Google Scholar
Donati, S. et al. Vitreous substitutes: the present and the future. Biomed. Res. Int. 2014, 351804 (2014).
Google Scholar
Huebsch, N. et al. Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Proc. Natl Acad. Sci. USA 111, 9762–9767 (2014).
Google Scholar
Chan, K. W. Y. et al. MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat. Mater. 12, 268–275 (2013).
Google Scholar
Merindol, R., Delechiave, G., Heinen, L., Catalani, L. H. & Walther, A. Modular design of programmable mechanofluorescent DNA hydrogels. Nat. Commun. 10, 528 (2019).
Google Scholar
Tan, J. et al. A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs. Osteoporos. Int. 27, 757–767 (2016).
Google Scholar
Tondera, C. et al. In vivo examination of an injectable hydrogel system crosslinked by peptide-oligosaccharide interaction in immunocompetent nude mice. Adv. Funct. Mater. 27, 1605189 (2017).
Zhang, M. et al. Real-time and noninvasive tracking of injectable hydrogel degradation using functionalized AIE nanoparticles. Nanophotonics 9, 2063–2075 (2020).
Google Scholar
Liao, R. et al. DNA-based engineering system for improving human and environmental health: Identification, detection, and treatment. Nano Today 35, 100958 (2020).
Google Scholar
Zhu, Z., Park, H. S. & McAlpine, M. C. 3D printed deformable sensors. Sci. Adv. 6, eaba5575 (2020).
Google Scholar
Tavakoli, J. & Tang, Y. Hydrogel based sensors for biomedical applications: an updated review. Polymers 9, 364 (2017).
Google Scholar
Crulhas, B. P., Recco, L. C., Delella, F. K. & Pedrosa, V. A. A novel superoxide anion biosensor for monitoring reactive species of oxygen released by cancer cells. Electroanalysis 29, 1252–1257 (2017).
Google Scholar
Wei, H. et al. Orthogonal photochemistry-assisted printing of 3D tough and stretchable conductive hydrogels. Nat. Commun. 12, 2082 (2021).
Google Scholar
Ohm, Y. et al. An electrically conductive silver-polyacrylamide-alginate hydrogel composite for soft electronics. Nat. Electron. 4, 185–192 (2021).
Google Scholar
Kim, B. S. et al. Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices. Sci. Adv. 6, eabc5630 (2020).
Google Scholar
Liu, X. et al. Ingestible hydrogel device. Nat. Commun. 10, 493 (2019).
Google Scholar
Kim, H. S., Abbas, N. & Shin, S. A rapid diagnosis of SARS-CoV-2 using DNA hydrogel formation on microfluidic pores. Biosens. Bioelectron. 177, 113005 (2021).
Google Scholar
Vijayasekaran, S. et al. Calcification of poly(2-hydroxyethyl methacrylate) hydrogel sponges implanted in the rabbit cornea: a 3-month study. J. Biomater. Sci. Polym. Ed. 11, 599–615 (2000).
Google Scholar
Yin, Y. et al. Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma. Nano Today 36, 101009 (2021).
Google Scholar
Wuschko, S. et al. Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease. Sci. Rep. 9, 5598 (2019).
Google Scholar
Osman, A. et al. Revisiting cancer stem cells as the origin of cancer-associated cells in the tumor microenvironment: a hypothetical view from the potential of iPSCs. Cancers 12, 879 (2020).
Google Scholar
Liu, C., Pei, H. & Tan, F. Matrix stiffness and colorectal cancer. Onco Targets Ther. 13, 2747–2755 (2020).
Google Scholar
Selig, M., Lauer, J. C., Hart, M. L. & Rolauffs, B. Mechanotransduction and stiffness-sensing: mechanisms and opportunities to control multiple molecular aspects of cell phenotype as a design cornerstone of cell-instructive biomaterials for articular cartilage repair. Int. J. Mol. Sci. 21, 5399 (2020).
Google Scholar
Jenkins, T. L. & Little, D. Synthetic scaffolds for musculoskeletal tissue engineering: cellular responses to fiber parameters. NPJ Regen. Med. 4, 15 (2019).
Google Scholar
