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GWAS identifies an ortholog of the rice D11 gene as a candidate gene for grain size in an international collection of hexaploid wheat

Phenotypic characterization of grain yield components To explore components of grain yield in wheat, we measured four phenotypes: grain length (Gle), grain width (Gwi), 1000-grain weight (Gwe) and grain yield…

Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy

1. Couzin-Frankel, J. Cancer immunotherapy. Science 342, 1432–1433 (2013). CAS  Article  Google Scholar  2. Gubin, M. M. et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, 577–581…

Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease

Four related peptides rescue MBNL-dependent missplicing events in DM1 myotubes Immortalized human DM1 muscle cell lines display disease-associated molecular features such as nuclear RNA aggregates and alternative splicing defects23. DM1-related…