Zipfel, C. Plant pattern recognition receptors. Trends Immunol. 35, 345–351 (2014).
Google Scholar
Lu, F. et al. Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR. J. Integrat. Plant Biol. https://doi.org/10.1111/jipb.12306 (2014).
Wu, Y. & Zhou, J. M. Receptor like kinases in plant innate immunity. J. Integr. Plant Biol. 55, 1271–1286 (2013).
Google Scholar
Kawano, Y. & Shimamoto, K. Early signaling network in rice PRR-mediated and R-mediated immunity. Curr. Opin. Plant Biol. 16, 496–504 (2013).
Google Scholar
Schwessinger, B. & Ronald, P. C. Plant innate immunity: perception of conserved microbial signatures. Annu. Rev. Plant Biol. 63, 451–482 (2012).
Google Scholar
Klarzynski, O. et al. Linear beta-1,3 glucans are elicitors of defense responses in tobacco. Plant Physiol. 124, 1027–1038 (2000).
Google Scholar
Kaku, H. et al. Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor. Proc. Natl Acad. Sci. USA 103, 11086–11091 (2006).
Google Scholar
Felix, G., Duran, J. D., Volko, S. & Boller, T. Plants have a sensitive perception system for the most conserved domain of bacterial flagellin. Plant J. 18, 265–276 (1999).
Google Scholar
Kunze, G. et al. The N terminus of bacterial elongation factor Tu elicits innate immunity in Arabidopsis plants. Plant Cell. 16, 3496–3507 (2004).
Google Scholar
Zipfel, C. et al. Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell 125, 749–760 (2006).
Google Scholar
Lacombe, S. et al. Interfamily transfer of a plant pattern recognition receptor confers broad-spectrum bacterial resistance. Nat. Biotechnol. 28, 365–369 (2009).
Google Scholar
Malnoy, M., Venisse, J. S., Faize, M., Geider, K. & Chevreau, E. Expression of viral EPS-depolymearse reduces fire blight susceptibility in transgenic pear. Plant Cell Rep. 23, 632–638 (2005).
Google Scholar
Pfeilmeier, S. et al. Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis. Plant Biotechnol. J. 17, 569–579 (2019).
Google Scholar
Boschi, F. et al. Enhanced bacterial wilt resistance in potato through expression of Arabidopsis EFR and introgression of quantitative resistance from Solanum commersonii. Front Plant Sci. 25, 1642 (2017). 8.
Google Scholar
Schwessinger, B. et al. Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand dependent activation of defense responses. PLoS Pathogen 11, e1004809 (2015).
Google Scholar
Schoonbeek, H. J. et al. Arabidopsis EF-TU receptor enhances bacterial disease resistance in transgenic wheat. N. Phytologist 206, 606–613 (2015).
Google Scholar
Malnoy, M. et al. Fire Blight: applied genomic insights of the pathogen and host. Annu. Rev. Phytopathol. 8, 475–494 (2012).
Google Scholar
Sundin, G. W., Castiblanco, L. F., Yuan, X., Zeng, Q. & Yang, C. H. Bacterial disease management: challenges, experience, innovation and future prospects. Mol. Plant Pathol. 17, 1506–1518 (2016).
Google Scholar
Broggini, G. A. et al. Engineering fire blight resistance into the apple cultivar ‘Gala’ using the FB_MR5 CC-NBS-LRR resistance gene of Malus x robusta 5. Plant Biotechnol. J. 12, 728–733 (2014).
Google Scholar
Durel, C. E., Denancé, C. & Brisset, M. N. Two distinct major QTL for resistance to fire blight co-localize on linkage group 12 in apple genotypes ‘Evereste’ and Malus floribunda clone 821. Genome 52, 139–147 (2009).
Google Scholar
Emeriewen, O. et al. Identification of a major quantitative trait locus for resistance to fire blight in the wild apple species Malus fusca. Mol. Breed. 34, 407–419 (2014).
Google Scholar
Emeriewen, O. F., Richter, K., Hanke, M. V., Malnoy, M. & Peil, A. The fire blight resistance QTL of Malus fusca (Mfu10) is affected but not broken down by the highly virulent Canadian Erwinia amylovora strain E2002A. Eur. J. Plant Pathol. 141, 631–635 (2015).
Google Scholar
Emeriewen, O. F., Richter, K., Hanke, M. V., Malnoy, M. & Peil, A. Further insights into Malus fusca fire blight resistance. J. Plant Pathol. 99, 45–49 (2017a).
Emeriewen, O. F. et al. Fire blight resistance of Malus ×arnoldiana is controlled by a quantitative trait locus located at the distal end of linkage group 12. Eur. J. Plant Pathol. 148, 1011–1018 (2017b).
Google Scholar
Emeriewen, O. F. et al. Towards map-based cloning of FB_Mfu10: identification of a receptor-like kinase candidate gene underlying the Malus fusca fire blight resistance locus on linkage group 10. Mol. Breed. 38, 106 (2018).
Google Scholar
Gardiner, S. E. et al. Putative resistance gene markers associated with quantitative trait loci for fire blight resistance in Malus ‘Robusta 5’ accessions. BMC Genet. 13, 1–20 (2012).
Google Scholar
Kost, T. D. et al. Development of the first cisgenic apple with increased resistance to fire blight. PLoS ONE 10, e0143980 (2015).
Google Scholar
Malnoy, M., Xu, M., Borejsza-Wysocka, E. E., Korban, S. S. & Aldwinckle, H. S. Two receptor-like genes, Vfa1 and Vfa2, confer resistance to the fungal pathogen Venturia inaequalis inciting apple scab disease. Mol. Plant-Microbe Interact. 21, 448–458 (2008).
Google Scholar
Malnoy, M., Reynoird, J. P., Borejsza-Wysocka, E. E. & Aldwinckle, H. S. Activation of the pathogen-inducible Gst1 promoter of potato after elicitation by Venturia ineaqualis and Erwinia amylovora in transgenic apple (Malus X domestica). Transgenic Res. 15, 83–93 (2006).
Google Scholar
Pitzschke, A., Djamei, A., Bitton, F. & Hirt, H. A major role of the MEKK1-MKK1/2-MPK4 pathway in ROS signaling. Mol. Plant 2, 120–137 (2009).
Google Scholar
Volk, G. M. et al. Ex situ conservation of vegetatively propagated species: development of a seed-based core collection for Malus sieversii. J. Am. Soc. Hort. Sci. 130, 203–210 (2005).
Google Scholar
Volk, G. M. et al. Genetic diversity and disease resistance of wild Malus orientalis from Turkey and Southern Russia. J. Am. Soc. Hort. Sci. 133, 383–389 (2008).
Google Scholar
Malnoy, M., Jin, Q., Borejsza-Wysocka, E., He, S. Y. & Aldwinckle, H. S. Over-expression of the Apple Gene MpNPR1 causes increased disease resistance in Malus X domestica. Mol. Plant-Microbe Interact. 20, 1568–1580 (2007).
Google Scholar
Malnoy, M., Venisse, J. S. & Chevreau, E. Expression of a bacterial effector, Harpin NEa, causes increased resistance to fire blight in Pyrus communis. Tree Genet. Genomes 1, 41–49 (2005).
Google Scholar
Vogt, I. et al. Gene-for-gene relationship in the host-pathogen system Malus x robusta 5-Erwinia amylovora. N. Phytol. 197, 1262–1275 (2013).
Google Scholar
Haroldsen, V. M. et al. Mobility of transgenic nucleic acids and proteins within grafted rootstocks for agricultural improvement. Front. Plant Sci. 3, 39 (2012).
Google Scholar
Mudge, K. et al. A history of grafting. Hortic. Rev. 35, 437–493 (2009).
Google Scholar
Pouget, R. Histoire de la Lutte contre le Phylloxera de la Vigne en France (Institut National de la Recherche Agronomique, Paris, 1990).
Kasai, A., Bai, S., Li, T. & Harada, T. Graft-transmitted siRNA signal from the root induces visual manifestation of endogenouspost-transcriptional gene silencing in the scion. PLoS ONE 6, e16895 (2011).
Google Scholar
Zhao, D. & Song, G. Rootstock-to-scion transfer of transgene derived small interfering RNAs and their effect on virus resistance in non transgenic sweet cherry. Plant Biotechnol. J. 12, 1319–1328 (2014).
Google Scholar
Kumar, S. et al. Transgenic expression of EFR and Ds2 genes for field management of bacterial wilt and bacterial spot of tomato. Phytopathology 108, 1042–1411 (2018).
Larkin, M. et al. Clustal W and clustal X version 2.0. Bioinformatics 23, 2947–2948 (2007).
Google Scholar
Bolar, J. P., Norelli, J. L., Aldwinckle, H. S. & Hanke, V. An efficient method for rooting and acclimation of micropropagated apple cultivar. HortScience 33, 1251–1252 (1998).
Google Scholar
Borejsza-Wysocka, E., Norelli, J. L., Aldwinckle, H. S. & Malnoy, M. Long-tern stability of attacin E expression in transformed apple after 12 years in the field and effect of the expression of this gene in the fruit characteristics. BMC Biotechnol. 10, 41 (2010).
Google Scholar
Müller, K. et al. In vivo cell wall loosening by hydroxyl radicals during cress seed germination and elongation growth. Plant Physiol. 150, 1855–1865 (2009).
Google Scholar
Venisse, J. S., Gullner, G. & Brisset, M. N. Evidence for the involvement of an oxidative stress in the initiation of infection of pear by Erwinia amylovora. Plant Physiol. 125, 2164–2172 (2001).
Google Scholar
Dalla Costa, L. et al. Development of a Taqman Real-time PCR method to quantify nptII in apple lines obtained with ‘established’ or ‘new breeding’ techniques of genetic modification. Food Anal. Methods 245, 643–652 (2019).
Google Scholar
Campa, M. et al. HIPMis a susceptibility gene of Malus: reduced expression reduces susceptibility to Erwinia amylovora. Mol. Plant-Microbe Interact. 32, 167–175 (2019).
Google Scholar
Pompili, V., Dalla Costa, L., Piazza, S., Pindo, M. & Malnoy, M. Reduced fire blight susceptibility in apple cultivars using a high-efficiency CRISPR/Cas9-FLP/FRT-based gene editing system. Plant Biotechnol. J. 18, 845–858 (2020).
Google Scholar
Beranger, R. et al. Agricultural and domestic pesticides in house dust from different agricultural areas in France. Environ. Sci. Pollut. Res. 26, 19632–19645 (2019).
Google Scholar
Holtappels, M., Noben, J. P. & Valcke, R. Virulence of Erwinia amylovora a prevalent apple pathogen; Outer membrane proteins and type III secreted effectors increase fitness and compromise plant defenses. Proteomics 16, 2377–2390 (2016).
Google Scholar
Steinberg, E. M. & Beer, S. V. Creation and complementation of pathogenicity mutants of Erwinia amylovora. Mol. Plant Microbe Interact. 1, 135–144 (1988).
Google Scholar

