Rossi, G., Manfrin, A. & Lutolf, M. P. Progress and potential in organoid research. Nat. Rev. Genet. 19, 671–687 (2018).
Google Scholar
Clevers, H. Modeling development and disease with organoids. Cell 165, 1586–1597 (2016).
Google Scholar
Lancaster, M. A. & Knoblich, J. A. Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125 (2014).
Google Scholar
Sasai, Y. Cytosystems dynamics in self-organization of tissue architecture. Nature 493, 318–326 (2013).
Google Scholar
Huch, M., Knoblich, J. A., Lutolf, M. P. & Martinez-Arias, A. The hope and the hype of organoid research. Development 144, 938–941 (2017).
Google Scholar
Gjorevski, N., Ranga, A. & Lutolf, M. P. Bioengineering approaches to guide stem cell-based organogenesis. Development 141, 1794–1804 (2014).
Google Scholar
Blondel, D. & Lutolf, M. P. Bioinspired hydrogels for 3D organoid culture. Chimia 73, 81–85 (2019).
Google Scholar
Wang, H. & Heilshorn, S. C. Adaptable hydrogel networks with reversible linkages for tissue engineering. Adv. Mater. 27, 3717–3736 (2015).
Google Scholar
Gjorevski, N. et al. Designer matrices for intestinal stem cell and organoid culture. Nature 539, 560–564 (2016).
Google Scholar
DiMarco, R. L., Dewi, R. E., Bernal, G., Kuo, C. & Heilshorn, S. C. Protein-engineered scaffolds for in vitro 3D culture of primary adult intestinal organoids. Biomater. Sci. 3, 1376–1385 (2015).
Google Scholar
Ng, S., Tan, W. J., Pek, M. M. X., Tan, M.-H. & Kurisawa, M. Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture. Biomaterials 219, 119400 (2019).
Google Scholar
Ranga, A. et al. Neural tube morphogenesis in synthetic 3D microenvironments. Proc. Natl Acad. Sci. USA 113, E6831–E6839 (2016).
Google Scholar
Ye, S. et al. A chemically defined hydrogel for human liver organoid culture. Adv. Funct. Mater. 30, 2000893 (2020).
Google Scholar
Rezakhani, S., Gjorevski, N. & Lutolf, M. P. Low-defect thiol-Michael addition hydrogels as Matrigel substitutes for epithelial organoid derivation. Adv. Funct. Mater. 30, 2000761 (2020).
Google Scholar
Cruz-Acuña, R. et al. Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat. Cell Biol. 19, 1326–1335 (2017).
Google Scholar
Hernandez-Gordillo, V. et al. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials 254, 120125 (2020).
Google Scholar
Lutolf, M. P. & Hubbell, J. A. Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition. Biomacromolecules 4, 713–722 (2003).
Google Scholar
Shugar, D. & Fox, J. J. Spectrophotometric studies of nucleic acid derivatives and related compounds as a function of pH. I. Pyrimidines. Biochim. Biophys. Acta 9, 199–218 (1952).
Google Scholar
Dankers, P. Y. W. et al. Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system. Adv. Mater. 24, 2703–2709 (2012).
Google Scholar
Ye, X. et al. Self-healing pH-sensitive cytosine- and guanosine-modified hyaluronic acid hydrogels via hydrogen bonding. Polymer 108, 348–360 (2017).
Google Scholar
Bastings, M. M. C. et al. A fast pH-switchable and self-healing supramolecular hydrogel carrier for guided, local catheter injection in the infarcted myocardium. Adv. Healthc. Mater. 3, 70–78 (2014).
Google Scholar
Hamada, N. & Einaga, Y. Effects of hydrophobic chain length on the characteristics of the micelles of octaoxyethylene tetradecyl C14E8, hexadecyl C16E8, and octadecyl C18E8 ethers. J. Phys. Chem. B 109, 6990–6998 (2005).
Google Scholar
Génin, F., Quilès, F. & Burneau, A. Infrared and Raman spectroscopic study of carboxylic acids in heavy water. Phys. Chem. Chem. Phys. 3, 932–942 (2001).
Google Scholar
Badasyan, A., Mavrič, A., Cigić, I. K., Bencik, T. & Valant, M. Polymer nanoparticle sizes from dynamic light scattering and size exclusion chromatography: the case study of polysilanes. Soft Matter 14, 4735–4740 (2018).
Google Scholar
Coleman, M. M., Lee, K. H., Skrovanek, D. J. & Painter, P. C. Hydrogen bonding in polymers. 4. Infrared temperature studies of a simple polyurethane. Macromolecules 19, 2149–2157 (1986).
Google Scholar
Cortese, J., Soulié-Ziakovic, C., Cloitre, M., Tencé-Girault, S. & Leibler, L. Order–disorder transition in supramolecular polymers. J. Am. Chem. Soc. 133, 19672–19675 (2011).
Google Scholar
Chan, J. W., Hoyle, C. E., Lowe, A. B. & Bowman, M. Nucleophile-initiated thiol-Michael reactions: effect of organocatalyst, thiol, and ene. Macromolecules 43, 6381–6388 (2010).
Google Scholar
Peppas, N. A. & Merrill, E. W. Poly(vinyl alcohol) hydrogels: reinforcement of radiation-crosslinked networks by crystallization. J. Polym. Sci. Polym. Chem. Ed. 14, 441–457 (1976).
Google Scholar
Chaudhuri, O. Viscoelastic hydrogels for 3D cell culture. Biomater. Sci. 5, 1480–1490 (2017).
Google Scholar
Dosh, R. H., Jordan-Mahy, N., Sammon, C. & Maitre, C. L. L. Use of L-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering. Biomater. Sci. 7, 4310–4324 (2019).
Google Scholar
Babaei, B., Davarian, A., Pryse, K. M., Elson, E. L. & Genin, G. M. Efficient and optimized identification of generalized Maxwell viscoelastic relaxation spectra. J. Mech. Behav. Biomed. Mater. 55, 32–41 (2016).
Google Scholar
Chaudhuri, O. et al. Hydrogels with tunable stress relaxation regulate stem cell fate and activity. Nat. Mater. 15, 326–334 (2016).
Google Scholar
Zhao, X., Huebsch, N., Mooney, D. J. & Suo, Z. Stress-relaxation behavior in gels with ionic and covalent crosslinks. J. Appl. Phys. 107, 063509 (2010).
Google Scholar
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009).
Google Scholar
Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190–1194 (2013).
Google Scholar
Yang, Q. et al. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nat. Cell Biol. 23, 733–744 (2021).
Google Scholar
Serra, D. et al. Self-organization and symmetry breaking in intestinal organoid development. Nature 569, 66–72 (2019).
Google Scholar
Broguiere, N. et al. Growth of epithelial organoids in a defined hydrogel. Adv. Mater. 30, e1801621 (2018).
Google Scholar
Lee, H.-P., Gu, L., Mooney, D. J., Levenston, M. E. & Chaudhuri, O. Mechanical confinement regulates cartilage matrix formation by chondrocytes. Nat. Mater. 16, 1243–1251 (2017).
Google Scholar
Yin, X. et al. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nat. Methods 11, 106–112 (2014).
Google Scholar
Panciera, T., Azzolin, L., Cordenonsi, M. & Piccolo, S. Mechanobiology of YAP and TAZ in physiology and disease. Nat. Rev. Mol. Cell Biol. 18, 758–770 (2017).
Google Scholar
Lukonin, I. et al. Phenotypic landscape of intestinal organoid regeneration. Nature 586, 275–280 (2020).
Google Scholar
Chaudhuri, O. et al. Substrate stress relaxation regulates cell spreading. Nat. Commun. 6, 6364 (2015).
Google Scholar
Broguiere, N., Formica, F. A., Barreto, G. & Zenobi-Wong, M. Sortase A as a cross-linking enzyme in tissue engineering. Acta Biomater. 77, 182–190 (2018).
Google Scholar
Valdez, J. et al. On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks. Biomaterials 130, 90–103 (2017).
Google Scholar
Fujii, M. et al. Human intestinal organoids maintain self-renewal capacity and cellular diversity in niche-inspired culture condition. Cell Stem Cell 23, 787–793 (2018).
Google Scholar
He, S. et al. Stiffness regulates intestinal stem cell fate. Preprint at https://doi.org/10.1101/2021.03.15.435410 (2021).
Zhang, J. et al. Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation. Adv. Mater. 23, 5098–5103 (2011).
Google Scholar
Shin, S. R. et al. Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide. Adv. Mater. 25, 6385–6391 (2013).
Google Scholar
Hong, S. et al. 3D printing of highly stretchable and tough hydrogels into complex, cellularized structures. Adv. Mater. 27, 4035–4040 (2015).
Google Scholar
Miyoshi, H. & Stappenbeck, T. S. In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture. Nat. Protoc. 8, 2471–2482 (2013).
Google Scholar
Chen, I., Dorr, B. M. & Liu, D. R. A general strategy for the evolution of bond-forming enzymes using yeast display. Proc. Natl Acad. Sci. USA 108, 11399–11404 (2011).
Google Scholar
