Abbott, N. J., Pizzo, M. E., Preston, J. E., Janigro, D. & Thorne, R. G. The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system? Acta Neuropathol. 135, 387–407 (2018).
Google Scholar
Sweeney, M. D., Sagare, A. P. & Zlokovic, B. V. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat. Rev. Neurol. 14, 133–150 (2018).
Google Scholar
Dong, X. Current strategies for brain drug delivery. Theranostics 8, 1481–1493 (2018).
Google Scholar
Tosi, G., Costantino, L., Ruozi, B., Forni, F. & Vandelli, M. A. Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opin. Drug Deliv. 5, 155–174 (2008).
Google Scholar
Jacobs, W. B. & Fehlings, M. G. The molecular basis of neural regeneration. Neurosurgery 53, 943–948 (2003). discussion 948-950.
Ran, W. & Xue, X. Theranostical application of nanomedicine for treating central nervous system disorders. Sci. China Life Sci. 61, 392–399 (2018).
Google Scholar
Lisik K. & Krokosz A. Application of carbon nanoparticles in oncology and regenerative medicine. Int. J. Mol. Sci. 22, 8341 (2021).
Guan, Y. et al. Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-beta peptide. Biomaterials 98, 92–102 (2016).
Google Scholar
Mason, C. & Dunnill, P. A brief definition of regenerative medicine. Regen. Med. 3, 1–5 (2008).
Yu, D. et al. MOF-encapsulated nanozyme enhanced siRNA combo: control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer’s disease model. Biomaterials 255, 120160 (2020).
Google Scholar
Sun, H. et al. Wireless near-infrared electrical stimulation of neurite outgrowth. Chem. Commun. 55, 9833–9836 (2019).
Google Scholar
Bellotti, E., Schilling, A. L., Little, S. R. & Decuzzi, P. Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: a review. J. Control Release 329, 16–35 (2021).
Google Scholar
Pakulska, M. M., Ballios, B. G. & Shoichet, M. S. Injectable hydrogels for central nervous system therapy. Biomed. Mater. 7, 024101 (2012).
Barchet, T. M. & Amiji, M. M. Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases. Expert Opin. Drug Deliv. 6, 211–225 (2009).
Google Scholar
Oller-Salvia, B., Sanchez-Navarro, M., Giralt, E. & Teixido, M. Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery. Chem. Soc. Rev. 45, 4690–4707 (2016).
Google Scholar
Kou, L. et al. L-Carnitine-conjugated nanoparticles to promote permeation across blood-brain barrier and to target glioma cells for drug delivery via the novel organic cation/carnitine transporter OCTN2. Artif. Cells Nanomed. Biotechnol. 46, 1605–1616 (2018).
Google Scholar
Akhtar, A. et al. Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics. J. Control Release 330, 1152–1167 (2021).
Google Scholar
Uchida, Y., Zhang, Z., Tachikawa, M. & Terasaki, T. Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen. J. Neurochem. 134, 1104–1115 (2015).
Google Scholar
Lu, C. T. et al. Current approaches to enhance CNS delivery of drugs across the brain barriers. Int. J. Nanomed. 9, 2241–2257 (2014).
Stockwell, J., Abdi, N., Lu, X., Maheshwari, O. & Taghibiglou, C. Novel central nervous system drug delivery systems. Chem. Biol. Drug Des. 83, 507–520 (2014).
Google Scholar
Kasinathan, N., Jagani, H. V., Alex, A. T., Volety, S. M. & Rao, J. V. Strategies for drug delivery to the central nervous system by systemic route. Drug Deliv. 22, 243–257 (2015).
Google Scholar
Kumari, A., Yadav, S. K. & Yadav, S. C. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf. B Biointerfaces 75, 1–18 (2010).
Google Scholar
De, WitteE. et al. A valid alternative for in-person language assessments in brain tumor patients: feasibility and validity measures of the new TeleLanguage test. Neurooncol Pract. 6, 93–102 (2019).
Rogawski, M. A. Convection-enhanced delivery in the treatment of epilepsy. Neurotherapeutics 6, 344–351 (2009).
Google Scholar
Yin, D. et al. Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model. Cancer Gene Ther. 20, 336–341 (2013).
Google Scholar
Qu, Y. et al. Injectable and thermosensitive hydrogel and PDLLA electrospun nanofiber membrane composites for guided spinal fusion. ACS Appl. Mater. Interfaces 10, 4462–4470 (2018).
Google Scholar
Lee J. & Kang S. K. Principles for Controlling the Shape Recovery and Degradation Behavior of Biodegradable Shape-Memory Polymers in Biomedical Applications. Micromachines 12, 757 (2021).
Weber, L. M., Lopez, C. G. & Anseth, K. S. Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function. J. Biomed. Mater. Res A. 90, 720–729 (2009).
Baumann, M. D., Kang, C. E., Tator, C. H. & Shoichet, M. S. Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury. Biomaterials 31, 7631–7639 (2010).
Google Scholar
Van Tomme, S. R., Storm, G. & Hennink, W. E. In situ gelling hydrogels for pharmaceutical and biomedical applications. Int J. Pharm. 355, 1–18 (2008).
Ulndreaj, A., Badner, A. & Fehlings, M. G. Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury. F1000Res. 6, 1907 (2017).
Kim, S. et al. The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. Biomaterials 30, 4743–4751 (2009).
Google Scholar
Zou J. L. Peripheral nerve-derived matrix hydrogel promotes remyelination and inhibits synapse formation. Adv. Funct. Mater. 28, 1705739 (2018).
Hyder, A. A., Wunderlich, C. A., Puvanachandra, P., Gururaj, G. & Kobusingye, O. C. The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation 22, 341–353 (2007).
Fernandez-Gajardo, R. et al. Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement. CNS Drugs 28, 229–248 (2014).
Google Scholar
Qian, F. et al. In Situ implantable, post-trauma microenvironment-responsive, ROS Depletion Hydrogels for the treatment of Traumatic brain injury. Biomaterials 270, 120675 (2021).
Google Scholar
Duncan, T. & Valenzuela, M. Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Res. Ther. 8, 111 (2017).
Zhang, K. Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury. J. Mater. Chem. B. 6, 2982–2992 (2018).
Google Scholar
Sultan, M. T. Reinforced-hydrogel encapsulated hMSCs towards brain injury treatment by trans-septal approach. Biomaterials 266, 120413 (2021).
Google Scholar
Silver F. H., Kelkar N. & Deshmukh T. Molecular basis for mechanical properties of ECMs: proposed role of fibrillar collagen and proteoglycans in tissue biomechanics. Biomolecules 11, 1018 (2021).
Wang, T. W. et al. Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system. Nanoscale 9, 16281–16292 (2017).
Google Scholar
Silva, N. A., Sousa, N., Reis, R. L. & Salgado, A. J. From basics to clinical: a comprehensive review on spinal cord injury. Prog. Neurobiol. 114, 25–57 (2014).
Shultz, R. B. & Zhong, Y. Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury. Neural Regen. Res. 12, 702–713 (2017).
Google Scholar
Lanska, D. J. The influence of the two world wars on the development of rehabilitation for spinal cord injuries in the United States and Great Britain. Front. Neurol. Neurosci. 38, 56–67 (2016).
Assuncao-Silva, R. C., Gomes, E. D., Sousa, N., Silva, N. A. & Salgado, A. J. Hydrogels and cell based therapies in spinal cord injury regeneration. Stem Cells Int. 2015, 948040 (2015).
Nazemi, Z. et al. Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury. J. Control Release 321, 145–158 (2020).
Google Scholar
Sabelstrom, H., Stenudd, M. & Frisen, J. Neural stem cells in the adult spinal cord. Exp. Neurol. 260, 44–49 (2014).
Yang, Y. et al. Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury. Biomaterials 269, 120479 (2021).
Google Scholar
Chen, W. C. et al. Transplantation of mesenchymal stem cells for spinal cord injury: a systematic review and network meta-analysis. J. Transl. Med. 19, 178 (2021).
Yuan T. Highly permeable DNA supramolecular hydrogel promotes neurogenesis and functional recovery after completely transected spinal cord injury. Adv Mater. https://doi.org/10.1002/adma.202102428e2102428 (2021).
Aly, A. E. et al. Intranasal delivery of pGDNF DNA nanoparticles provides neuroprotection in the rat 6-hydroxydopamine model of Parkinson’s disease. Mol. Neurobiol. 56, 688–701 (2019).
Google Scholar
Sabir F. Development and characterization of n-propyl gallate encapsulated solid lipid nanoparticles-loaded hydrogel for intranasal delivery. Pharmaceuticals 14, 696 (2021).
Li, Y., Li, J., Zhang, X., Ding, J. & Mao, S. Non-ionic surfactants as novel intranasal absorption enhancers: in vitro and in vivo characterization. Drug Deliv. 23, 2272–2279 (2016).
Google Scholar
Pathak, R., Dash, R. P., Misra, M. & Nivsarkar, M. Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route. Acta Pharm. Sin. B. 4, 151–160 (2014).
Grover, S., Sahoo, S., Chakrabarti, S. & Avasthi, A. Post-traumatic stress disorder (PTSD) related symptoms following an experience of delirium. J. Psychosom. Res. 123, 109725 (2019).
Pang, L. et al. Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder. Acta Pharmaceutica Sin. B. 11, 2031–2047 (2021).
Google Scholar
Wang, Q. S. et al. Intranasal delivery of berberine via in situ thermoresponsive hydrogels with non-invasive therapy exhibits better antidepressant-like effects. Biomater. Sci. 8, 2853–2865 (2020).
Google Scholar
Jiang, Y. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience 172, 398–405 (2011).
Google Scholar
Su, X., Huang, L., Xiao, D., Qu, Y. & Mu, D. Research progress on the role and mechanism of action of activin A in brain injury. Front Neurosci. 12, 697 (2018).
Steidinger, T. U., Slone, S. R., Ding, H., Standaert, D. G. & Yacoubian, T. A. Angiogenin in Parkinson disease models: role of Akt phosphorylation and evaluation of AAV-mediated angiogenin expression in MPTP treated mice. PLoS ONE 8, e56092 (2013).
Google Scholar
Sun, Y. et al. Functional self-assembling peptide nanofiber hydrogels designed for nerve degeneration. ACS Appl Mater. Interfaces 8, 2348–2359 (2016).
Google Scholar
Guo, J. et al. Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine 5, 345–351 (2009).
Google Scholar
Adak, A. Biodegradable neuro-compatible peptide hydrogel promotes neurite outgrowth, shows significant neuroprotection, and delivers anti-Alzheimer drug. ACS Appl Mater. Interfaces 9, 5067–5076 (2017).
Google Scholar
Clarkin, O. M. et al. Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering. Carbohydr. Polym. 217, 152–159 (2019).
Google Scholar
Li, J. et al. A drug delivery hydrogel system based on activin B for Parkinson’s disease. Biomaterials 102, 72–86 (2016).
Google Scholar
Wang, J. T. et al. Enhanced delivery of neuroactive drugs via nasal delivery with a self-healing supramolecular gel. Adv. Sci. 8, e2101058 (2021).
Adil, M. M. et al. Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons. Biomaterials 136, 1–11 (2017).
Google Scholar
Moriarty, N., Cabre, S., Alamilla, V., Pandit, A. & Dowd, E. Encapsulation of young donor age dopaminergic grafts in a GDNF-loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi-Parkinsonian rats. Eur. J. Neurosci. 49, 487–496 (2019).
Adil M. M. Dopaminergic neurons transplanted using cell-instructive biomaterials alleviate parkinsonism in rodents. Adv. Funct. Mater. 28, 1804144 (2018).
Wei, X., Chen, X., Ying, M. & Lu, W. Brain tumor-targeted drug delivery strategies. Acta Pharm. Sin. B. 4, 193–201 (2014).
Bastiancich, C. et al. Injectable nanomedicine hydrogel for local chemotherapy of glioblastoma after surgical resection. J. Control Release 264, 45–54 (2017).
Google Scholar
Medikonda R. et al. Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma. J. Neurosurg. https://doi.org/10.3171/2021.1.JNS2024821-10 (2021).
Tsao, C. T. Thermoreversible poly(ethylene glycol)-g-chitosan hydrogel as a therapeutic T lymphocyte depot for localized glioblastoma immunotherapy. Biomacromolecules 15, 2656–2662 (2014).
Google Scholar
Huse, J. T. & Holland, E. C. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 10, 319–331 (2010).
Google Scholar
Bellail, A. C., Hunter, S. B., Brat, D. J., Tan, C. & Van Meir, E. G. Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J. Biochem. Cell Biol. 36, 1046–1069 (2004).
Google Scholar
Moon H. et al. Delta(8(14))-ergostenol glycoside derivatives inhibit the expression of inflammatory mediators and matrix metalloproteinase. Molecules 26, 4547 (2021).
Cha, J. & Kim, P. Cancer cell-sticky hydrogels to target the cell membrane of invading glioblastomas. ACS Appl Mater. Interfaces 13, 31371–31378 (2021).
Google Scholar
Osuka, S. & Van Meir, E. G. Overcoming therapeutic resistance in glioblastoma: the way forward. J. Clin. Investig. 127, 415–426 (2017).
Schiapparelli, P. et al. Self-assembling and self-formulating prodrug hydrogelator extends survival in a glioblastoma resection and recurrence model. J. Control Release 319, 311–321 (2020).
Google Scholar
Cheetham, A. G., Zhang, P., Lin, Y. A., Lin, R. & Cui, H. Synthesis and self-assembly of a Mikto-Arm star dual drug amphiphile containing both paclitaxel and camptothecin. J. Mater. Chem. B. 2, 7316–7326 (2014).
Google Scholar
Lin, R., Cheetham, A. G., Zhang, P., Lin, Y. A. & Cui, H. Supramolecular filaments containing a fixed 41% paclitaxel loading. Chem. Commun. 49, 4968–4970 (2013).
Google Scholar
Chakroun, R. W. et al. Fine-tuning the linear release rate of paclitaxel-bearing supramolecular filament hydrogels through molecular engineering. ACS Nano. 13, 7780–7790 (2019).
Google Scholar
Wang, F. et al. Supramolecular tubustecan hydrogel as chemotherapeutic carrier to improve tumor penetration and local treatment efficacy. ACS Nano. 14, 10083–10094 (2020).
Google Scholar
Ashby, L. S., Smith, K. A. & Stea, B. Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review. World J. Surg. Oncol. 14, 225 (2016).
Sage, W. et al. Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit. J. Neurooncol. 136, 273–280 (2018).
Google Scholar
Rowland, M. J., Atgie, M., Hoogland, D. & Scherman, O. A. Preparation and supramolecular recognition of multivalent peptide-polysaccharide conjugates by cucurbit[8]uril in hydrogel formation. Biomacromolecules 16, 2436–2443 (2015).
Google Scholar
Parkins C. C. et al. Mechanically matching the rheological properties of brain tissue for drug-delivery in human glioblastoma models. Biomaterials. https://doi.org/10.1016/j.biomaterials.2021.120919 (2021).
Chen Z. et al. Targeted delivery of CRISPR/Cas9-mediated cancer gene therapy via liposome-templated hydrogel nanoparticles. Adv. Funct. Mater. 27, 1703036 (2017).
Zhao, M. Codelivery of paclitaxel and temozolomide through a photopolymerizable hydrogel prevents glioblastoma recurrence after surgical resection. J. Control Release 309, 72–81 (2019).
Google Scholar
Aboseada, H. A., Hassanien, M. M., El-Sayed, I. H. & Saad, E. A. Schiff base 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide up-regulates the antioxidant status and inhibits the progression of Ehrlich solid tumor in mice. Biochem Biophys. Res. Commun. 573, 42–47 (2021).
Google Scholar
Majumder, P., Baxa, U., Walsh, S. T. R. & Schneider, J. P. Design of a multicompartment hydrogel that facilitates time-resolved delivery of combination therapy and synergized killing of glioblastoma. Angew. Chem. Int. Ed. Engl. 57, 15040–15044 (2018).
Google Scholar
Kim H. D. et al. Biomimetic materials and fabrication approaches for bone tissue engineering. Adv. Healthc. Mater. 6, 1700612 (2017).
Hendrickson, T. et al. Mimicking cardiac tissue complexity through physical cues: A review on cardiac tissue engineering approaches. Nanomedicine 33, 102367 (2021).
Google Scholar
Padfield, E., Ellis, H. P. & Kurian, K. M. Current therapeutic advances targeting EGFR and EGFRvIII in glioblastoma. Front. Oncol. 5, 5 (2015).
Jackman, D. et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J. Clin. Oncol. 28, 357–360 (2010).
Google Scholar
Pedron S., Hanselman J. S., Schroeder M. A., Sarkaria J. N. & Harley B. A. C. Extracellular hyaluronic acid influences the efficacy of EGFR tyrosine kinase inhibitors in a biomaterial model of glioblastoma. Adv. Healthc. Mater. 6, 1700529 (2017).
Pedron, S. et al. Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens. Biomaterials 219, 119371 (2019).
Google Scholar
Hardee, M. E. & Zagzag, D. Mechanisms of glioma-associated neovascularization. Am. J. Pathol. 181, 1126–1141 (2012).
Google Scholar
Vaupel, P. & Harrison, L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist 9(Suppl 5), 4–9 (2004).
Wang, C. et al. Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels. Biomaterials 202, 35–44 (2019).
Google Scholar
Mukherjee, N., Adak, A. & Ghosh, S. Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury. Soft Matter 16, 10046–10064 (2020).
Google Scholar
