Agapakis, C. M., Boyle, P. M. & Silver, P. A. Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat. Chem. Biol. 8, 527–535 (2012).
Google Scholar
Hammes, G. G. & Wu, C.-W. Regulation of enzyme activity. Science 172, 1205–1211 (1971).
Google Scholar
Kondo, S. & Miura, T. Reaction-diffusion model as a framework for understanding biological pattern formation. Science 329, 1616–1620 (2010).
Lim, W. A. Designing customized cell signalling circuits. Nat. Rev. Mol. Cell Biol. 11, 393–403 (2010).
Google Scholar
Han, D. et al. A cascade reaction network mimicking the basic functional steps of adaptive immune response. Nat. Chem. 7, 835–841 (2015).
Google Scholar
Semenov, S. N. et al. Rational design of functional and tunable oscillating enzymatic networks. Nat. Chem. 7, 160–165 (2015).
Google Scholar
Zhang, Y., Tsitkov, S. & Hess, H. Complex dynamics in a two-enzyme reaction network with substrate competition. Nat. Catal. 1, 276–281 (2018).
Google Scholar
Chen, W.-H., Vázquez-González, M., Zoabi, A., Abu-Reziq, R. & Willner, I. Biocatalytic cascades driven by enzymes encapsulated in metal–organic framework nanoparticles. Nat. Catal. 1, 689–695 (2018).
Google Scholar
Küchler, A., Yoshimoto, M., Luginbühl, S., Mavelli, F. & Walde, P. Enzymatic reactions in confined environments. Nat. Nanotechnol. 11, 409–420 (2016).
Google Scholar
Vázquez-González, M., Wang, C. & Willner, I. Biocatalytic cascades operating on macromolecular scaffolds and in confined environments. Nat. Catal. 3, 256–273 (2020).
Google Scholar
Einfalt, T. et al. Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment. Nat. Commun. 9, 1127 (2018).
Google Scholar
Buddingh’, B. C. & van Hest, J. C. M. Artificial cells: synthetic compartments with life-like functionality and adaptivity. Acc. Chem. Res. 50, 769–777 (2017).
Google Scholar
Staufer, O., Schröter, M., Platzman, I. & Spatz, J. P. Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics. Small 16, 1906424 (2020).
Google Scholar
van Oppen, L. M. P. E. et al. Biodegradable synthetic organelles demonstrate ROS shielding in human-complex-I-deficient fibroblasts. ACS Cent. Sci. 4, 917–928 (2018).
Google Scholar
Reinkemeier, C. D., Girona, G. E. & Lemke, E. A. Designer membraneless organelles enable codon reassignment of selected mRNAs in eukaryotes. Science 363, eaaw2644 (2019).
Google Scholar
Rideau, E., Dimova, R., Schwille, P., Wurm, F. R. & Landfester, K. Liposomes and polymersomes: a comparative review towards cell mimicking. Chem. Soc. Rev. 47, 8572–8610 (2018).
Google Scholar
Parodi, A. et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat. Nanotechnol. 8, 61–68 (2013).
Google Scholar
Hu, C.-M. J. et al. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc. Natl Acad. Sci. USA 108, 10980 (2011).
Google Scholar
Lee, K. Y. et al. Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system. Nat. Biotechnol. 36, 530–535 (2018).
Google Scholar
Weiss, M. et al. Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics. Nat. Mater. 17, 89–96 (2018).
Google Scholar
Yoo, J.-W., Irvine, D. J., Discher, D. E. & Mitragotri, S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat. Rev. Drug Discov. 10, 521–535 (2011).
Google Scholar
Grzybowski, B. A. & Huck, W. T. S. The nanotechnology of life-inspired systems. Nat. Nanotechnol. 11, 585–592 (2016).
Google Scholar
Miller, T. E. et al. Light-powered CO2 fixation in a chloroplast mimic with natural and synthetic parts. Science 368, 649–654 (2020).
Google Scholar
Kumar, S. et al. Human platelet membrane functionalized microchips with plasmonic codes for cancer detection. Adv. Funct. Mater. 29, 1902669 (2019).
Google Scholar
Kalluri, R. & LeBleu, V. S. The biology, function, and biomedical applications of exosomes. Science 367, eaau6977 (2020).
Google Scholar
El Andaloussi, S., Mäger, I., Breakefield, X. O. & Wood, M. J. A. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat. Rev. Drug Discov. 12, 347–357 (2013).
Google Scholar
Armstrong, J. P. K., Holme, M. N. & Stevens, M. M. Re-engineering extracellular vesicles as smart nanoscale therapeutics. ACS Nano 11, 69–83 (2017).
Google Scholar
Robbins, P. D. & Morelli, A. E. Regulation of immune responses by extracellular vesicles. Nat. Rev. Immunol. 14, 195–208 (2014).
Google Scholar
Hindley, J. W. et al. Light-triggered enzymatic reactions in nested vesicle reactors. Nat. Commun. 9, 1093 (2018).
Google Scholar
Ishmukhametov, R. R., Russell, A. N. & Berry, R. M. A modular platform for one-step assembly of multi-component membrane systems by fusion of charged proteoliposomes. Nat. Commun. 7, 13025 (2016).
Google Scholar
Bolognesi, G. et al. Sculpting and fusing biomimetic vesicle networks using optical tweezers. Nat. Commun. 9, 1882 (2018).
Google Scholar
Kumar, S., Michael, I. J., Park, J., Granick, S. & Cho, Y.-K. Cloaked exosomes: biocompatible, durable, and degradable encapsulation. Small 14, 1802052 (2018).
Google Scholar
Stengel, G., Simonsson, L., Campbell, R. A. & Höök, F. Determinants for membrane fusion induced by cholesterol-modified DNA zippers. J. Phys. Chem. B 112, 8264–8274 (2008).
Google Scholar
Jumeaux, C. et al. MicroRNA detection by DNA-mediated liposome fusion. ChemBioChem 19, 434–438 (2018).
Google Scholar
Barlow, N., Chalmers, D. K., Williams-Noonan, B. J., Thompson, P. E. & Norton, R. S. Improving membrane permeation in the beyond rule-of-five space by using prodrugs to mask hydrogen bond donors. ACS Chem. Biol. 15, 2070–2078 (2020).
Google Scholar
Stengel, G., Zahn, R. & Höök, F. DNA-induced programmable fusion of phospholipid vesicles. J. Am. Chem. Soc. 129, 9584–9585 (2007).
Google Scholar
Collins, D. J., Neild, A., deMello, A., Liu, A.-Q. & Ai, Y. The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation. Lab Chip 15, 3439–3459 (2015).
Google Scholar
Huang, F. et al. Near-infrared light-activated membrane fusion for cancer cell therapeutic applications. Chem. Sci. 11, 5592–5600 (2020).
Google Scholar
Piffoux, M., Silva, A. K. A., Wilhelm, C., Gazeau, F. & Tareste, D. Modification of extracellular vesicles by fusion with liposomes for the design of personalized biogenic drug delivery systems. ACS Nano 12, 6830–6842 (2018).
Google Scholar
Leidal, A. M. et al. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat. Cell Biol. 22, 187–199 (2020).
Google Scholar
Fuentes, P. et al. ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells. Nat. Commun. 11, 4261 (2020).
Google Scholar
Joshi, B. S., de Beer, M. A., Giepmans, B. N. G. & Zuhorn, I. S. Endocytosis of extracellular vesicles and release of their cargo from endosomes. ACS Nano 14, 4444–4455 (2020).
Google Scholar
Xu, Y. et al. Nanozyme-catalyzed cascade reactions for mitochondria-mimicking oxidative phosphorylation. Angew. Chem. Int. Ed. 58, 5572–5576 (2019).
Google Scholar
Jeong, S., Nguyen, H. T., Kim, C. H., Ly, M. N. & Shin, K. Toward artificial cells: novel advances in energy conversion and cellular motility. Adv. Funct. Mater. 30, 1907182 (2020).
Google Scholar
Schütt, F., Aretz, S., Auffarth, G. U. & Kopitz, J. Moderately reduced ATP levels promote oxidative stress and debilitate autophagic and phagocytic capacities in human RPE cells. Investig. Ophthalmol. Vis. Sci. 53, 5354–5361 (2012).
Google Scholar
Lenzini, S., Bargi, R., Chung, G. & Shin, J.-W. Matrix mechanics and water permeation regulate extracellular vesicle transport. Nat. Nanotechnol. 15, 217–223 (2020).
Google Scholar
Yong, T. et al. Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy. Nat. Commun. 10, 3838 (2019).
Google Scholar
Borkowska, M. et al. Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells. Nat. Nanotechnol. 15, 331–341 (2020).
Google Scholar
Feder, T. J., Brust-Mascher, I., Slattery, J. P., Baird, B. & Webb, W. W. Constrained diffusion or immobile fraction on cell surfaces: a new interpretation. Biophys. J. 70, 2767–2773 (1996).
Google Scholar
Nandi, A., Heinrich, D. & Lindner, B. Distributions of diffusion measures from a local mean-square displacement analysis. Phys. Rev. E 86, 021926 (2012).
Google Scholar
Ishmukhametov, R. R., Galkin, M. A. & Vik, S. B. Ultrafast purification and reconstitution of His-tagged cysteine-less Escherichia coli F1Fo ATP synthase. Biochim. Biophys. Acta 1706, 110–116 (2005).
Google Scholar
Rumbley, J. N., Furlong Nickels, E. & Gennis, R. B. One-step purification of histidine-tagged cytochrome bo3 from Escherichia coli and demonstration that associated quinone is not required for the structural integrity of the oxidase. Biochim. Biophys. Acta 1340, 131–142 (1997).
Google Scholar
