Tilman, D., Balzer, C., Hill, J. & Befort, B. L. Global food demand and the sustainable intensification of agriculture. Proc. Natl Acad. Sci. USA 108, 20260–20264 (2011).
Google Scholar
Timmis, J. N., Ayliffe, M. A., Huang, C. Y. & Martin, W. Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes. Nat. Rev. Genet. 5, 123–135 (2004).
Google Scholar
Boehm, C. R. & Bock, R. Recent advances and current challenges in synthetic biology of the plastid genetic system and metabolism. Plant Physiol. 179, 794–802 (2019).
Google Scholar
Allen, J. F. Why chloroplasts and mitochondria retain their own genomes and genetic systems: colocation for redox regulation of gene expression. Proc. Natl Acad. Sci. USA 112, 10231–10238 (2015).
Google Scholar
Chan, K. X., Phua, S. Y., Crisp, P., McQuinn, R. & Pogson, B. J. Learning the languages of the chloroplast: retrograde signaling and beyond. Annu. Rev. Plant Biol. 67, 25–53 (2016).
Google Scholar
Sowden, R. G., Watson, S. J. & Jarvis, P. The role of chloroplasts in plant pathology. Essays Biochem. 62, 21–39 (2018).
Google Scholar
Unal, D., Garcia-Caparros, P., Kumar, V. & Dietz, K. J. Chloroplast-associated molecular patterns as concept for fine-tuned operational retrograde signalling. Philos. Trans. R. Soc. B 375, 20190443 (2020).
Google Scholar
Dietz, K. J. Efficient high light acclimation involves rapid processes at multiple mechanistic levels. J. Exp. Bot. 66, 2401–2414 (2015).
Google Scholar
Savary, S. et al. The global burden of pathogens and pests on major food crops. Nat. Ecol. Evol. 3, 430–439 (2019).
Google Scholar
de Torres Zabala, M. et al. Chloroplasts play a central role in plant defence and are targeted by pathogen effectors. Nat. Plants 1, 15074 (2015).
Google Scholar
Gao, C. et al. Pathogen manipulation of chloroplast function triggers a light-dependent immune recognition. Proc. Natl Acad. Sci. USA 117, 9613–9620 (2020).
Google Scholar
Rodriguez-Herva, J. J. et al. A bacterial cysteine protease effector protein interferes with photosynthesis to suppress plant innate immune responses. Cell Microbiol. 14, 669–681 (2012).
Google Scholar
Smith, N. A., Eamens, A. L. & Wang, M. B. Viral small interfering RNAs target host genes to mediate disease symptoms in plants. PLoS Pathog. 7, e1002022 (2011).
Google Scholar
Yu, G. et al. A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity. PLoS Pathog. 16, e1008933 (2020).
Google Scholar
Nekrasov, V. et al. Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion. Sci. Rep. 7, 482 (2017).
Google Scholar
Blanco, N. E. et al. Expression of the minor isoform pea ferredoxin in tobacco alters photosynthetic electron partitioning and enhances cyclic electron flow. Plant Physiol. 161, 866–879 (2013).
Google Scholar
Hussey, B. J. & McMillen, D. R. Programmable T7-based synthetic transcription factors. Nucleic Acids Res. 46, 9842–9854 (2018).
Google Scholar
McBride, K. E., Schaaf, D. J., Daley, M. & Stalker, D. M. Controlled expression of plastid transgenes in plants based on a nuclear DNA-encoded and plastid-targeted T7 RNA polymerase. Proc. Natl Acad. Sci. USA 91, 7301–7305 (1994).
Google Scholar
Yin, Z., Machius, M., Nestler, E. J. & Rudenko, G. Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res. 45, 11425–11436 (2017).
Google Scholar
Sicilia, M. N. A., Romero, M. E. S., Rosales, M. P. R. & Venema, K. Plastidial transporters KEA1 and KEA2 at the inner envelope membrane adjust stromal pH in the dark. N. Phytol. 229, 2080–2090 (2021).
Google Scholar
Mazzei, L., Cianci, M., Benini, S. & Ciurli, S. The impact of pH on catalytically critical protein conformational changes: the case of the urease, a nickel enzyme. Chemistry 25, 12145–12158 (2019).
Google Scholar
Hall, T. M. De-coding and re-coding RNA recognition by PUF and PPR repeat proteins. Curr. Opin. Struct. Biol. 36, 116–121 (2016).
Google Scholar
Bally, J. et al. Plant physiological adaptations to the massive foreign protein synthesis occurring in recombinant chloroplasts. Plant Physiol. 150, 1474–1481 (2009).
Google Scholar
Lentz, E. M. et al. High expression level of a foot and mouth disease virus epitope in tobacco transplastomic plants. Planta 231, 387–395 (2010).
Google Scholar
Occhialini, A. et al. Mini-synplastomes for plastid genetic engineering. Plant Biotechnol. J. https://doi.org/10.1111/pbi.13717 (2021).
Chen, J. H. et al. Nuclear-encoded synthesis of the D1 subunit of photosystem II increases photosynthetic efficiency and crop yield. Nat. Plants 6, 570–580 (2020).
Google Scholar
Saxena, B. et al. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. J. Biosci. 39, 33–41 (2014).
Google Scholar
Llorente, B. et al. Synthetic conversion of leaf chloroplasts into carotenoid-rich plastids reveals mechanistic basis of natural chromoplast development. Proc. Natl Acad. Sci. USA 117, 21796–21803 (2020).
Google Scholar
Llorente, B., Williams, T. C. & Goold, H. D. The multiplanetary future of plant synthetic biology. Genes 9, 348 (2018).
Google Scholar
Wurtzel, E. T. et al. Revolutionizing agriculture with synthetic biology. Nat. Plants 5, 1207–1210 (2019).
Google Scholar
