Allen, T. M. & Cullis, P. R. Drug delivery systems: entering the mainstream. Science 303, 1818–1822 (2004).
Google Scholar
Yoo, J. W., Irvine, D. J., Discher, D. E. & Mitragotri, S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat. Rev. Drug Discov. 10, 521–535 (2011).
Google Scholar
Lyerly, H. K., Osada, T. & Hartman, Z. C. Right time and place for IL12: targeted delivery stimulates immune therapy. Clin. Cancer Res. 25, 9–11 (2019).
Google Scholar
Fioranelli, M. & Roccia, M. G. Twenty-five years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigm. J. Integr. Cardiol. 1, 2–6 (2014).
Samanta, S. et al. Exosomes: new molecular targets of diseases. Acta Pharmacol. Sin. 39, 501–513 (2018).
Google Scholar
Han, X., Wang, C. & Liu, Z. Red blood cells as smart delivery systems. Bioconjugate Chem. 29, 852–860 (2018).
Google Scholar
Fang, R. H., Kroll, A. V., Gao, W. & Zhang, L. Cell membrane coating nanotechnology. Adv. Mater. 30, e1706759 (2018).
Google Scholar
Thanuja, M. Y., Anupama, C. & Ranganath, S. H. Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: so near and yet so far. Adv. Drug Deliv. Rev. 132, 57–80 (2018).
Google Scholar
Labusca, L., Herea, D. D. & Mashayekhi, K. Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives. World J. Stem Cells 10, 43–56 (2018).
Google Scholar
Sackstein, R. The lymphocyte homing receptors: gatekeepers of the multistep paradigm. Curr. Opin. Hematol. 12, 444–450 (2005).
Google Scholar
Nitzsche, F. et al. Concise review: MSC adhesion cascade–insights into homing and transendothelial migration. Stem Cells 35, 1446–1460 (2017).
Google Scholar
Ullah, M., Liu, D. D. & Thakor, A. S. Mesenchymal stromal cell homing: mechanisms and strategies for improvement. iScience 15, 421–438 (2019).
Google Scholar
Fischer, U. M. et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev. 18, 683–692 (2009).
Google Scholar
Karp, J. M. & Leng Teo, G. S. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4, 206–216 (2009).
Google Scholar
Galipeau, J. & Sensebe, L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell 22, 824–833 (2018).
Google Scholar
Marks, P. W., Witten, C. M. & Califf, R. M. Clarifying stem-cell therapy’s benefits and risks. N. Engl. J. Med. 376, 1007–1009 (2017).
Google Scholar
Wigler, M. H. & Weinstein, I. B. A preparative method for obtaining enucleated mammalian cells. Biochem. Biophys. Res. Commun. 63, 669–674 (1975).
Google Scholar
Shay, J. W. Cell enucleation, cybrids, reconstituted cells, and nuclear hybrids. Methods Enzymol. 151, 221–237 (1987).
Google Scholar
Coimbra, V. C. et al. Enucleated L929 cells support invasion, differentiation, and multiplication of Trypanosoma cruzi parasites. Infect. Immun. 75, 3700–3706 (2007).
Google Scholar
Graham, D. M. et al. Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction. J. Cell Biol. 217, 895–914 (2018).
Google Scholar
Wolbank, S. et al. Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics. Tissue Eng. Part A 15, 1843–1854 (2009).
Google Scholar
Malawista, S. E., Van Blaricom, G. & Breitenstein, M. G. Cryopreservable neutrophil surrogates. Stored cytoplasts from human polymorphonuclear leukocytes retain chemotactic, phagocytic, and microbicidal function. J. Clin. Invest. 83, 728–732 (1989).
Google Scholar
Keys, J., Windsor, A. & Lammerding, J. Assembly and use of a microfluidic device to study cell migration in confined environments. Methods Mol. Biol. 1840, 101–118 (2018).
Google Scholar
Lammerding, J. Mechanics of the nucleus. Compr. Physiol. 1, 783–807 (2011).
Google Scholar
Guilak, F., Tedrow, J. R. & Burgkart, R. Viscoelastic properties of the cell nucleus. Biochem. Biophys. Res. Commun. 269, 781–786 (2000).
Google Scholar
Stewart-Hutchinson, P. J., Hale, C. M., Wirtz, D. & Hodzic, D. Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell. Res. 314, 1892–1905 (2008).
Google Scholar
Caille, N., Thoumine, O., Tardy, Y. & Meister, J. J. Contribution of the nucleus to the mechanical properties of endothelial cells. J. Biomech. 35, 177–187 (2002).
Google Scholar
Marquez-Curtis, L. A. & Janowska-Wieczorek, A. Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1/CXCR4 axis. BioMed. Res. Int. 2013, 561098 (2013).
Google Scholar
Pandolfi, F. et al. Integrins: integrating the biology and therapy of cell–cell interactions. Clin. Ther. 39, 2420–2436 (2017).
Google Scholar
Chigaev, A. et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J. Biol. Chem. 276, 48670–48678 (2001).
Google Scholar
Boltze, J. et al. The dark side of the force – constraints and complications of cell therapies for stroke. Front. Neurol. 6, 155 (2015).
Google Scholar
Jung, J. W. et al. Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy. Yonsei Med. J. 54, 1293–1296 (2013).
Google Scholar
Bartosh, T. J. et al. Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties. Proc. Natl Acad. Sci. USA 107, 13724–13729 (2010).
Google Scholar
Levy, O. et al. mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. Blood 122, e23–e32 (2013).
Google Scholar
Gordon, S. et al. Antigen markers of macrophage differentiation in murine tissues. Curr. Top. Microbiol. Immunol. 181, 1–37 (1992).
Google Scholar
Devine, M. J., Mierisch, C. M., Jang, E., Anderson, P. C. & Balian, G. Transplanted bone marrow cells localize to fracture callus in a mouse model. J. Orthop. Res. 20, 1232–1239 (2002).
Google Scholar
Ignowski, J. M. & Schaffer, D. V. Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells. Biotechnol. Bioeng. 86, 827–834 (2004).
Google Scholar
Alvarez, H. M. et al. Effects of PEGylation and immune complex formation on the pharmacokinetics and biodistribution of recombinant interleukin 10 in mice. Drug Metab. Dispos. 40, 360–373 (2012).
Google Scholar
Greenberg, J. A. et al. Clinical practice guideline: management of acute pancreatitis. Can. J. Surg. 59, 128–140 (2016).
Google Scholar
Forsmark, C. E., Vege, S. S. & Wilcox, C. M. Acute Pancreatitis. N. Engl. J. Med. 375, 1972–1981 (2016).
Google Scholar
Niederau, C., Ferrell, L. D. & Grendell, J. H. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 88, 1192–1204 (1985).
Google Scholar
Su, K. H., Cuthbertson, C. & Christophi, C. Review of experimental animal models of acute pancreatitis. HPB 8, 264–286 (2006).
Google Scholar
Rongione, A. J. et al. Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 112, 960–967 (1997).
Google Scholar
van Laethem, J. L. et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 108, 1917–1922 (1995).
Google Scholar
Fedorak, R. N. et al. Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn’s disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 119, 1473–1482 (2000).
Google Scholar
Nowakowski, A., Andrzejewska, A., Janowski, M., Walczak, P. & Lukomska, B. Genetic engineering of stem cells for enhanced therapy. Acta Neurobiol. Exp. 73, 1–18 (2013).
Cui, L. L. et al. The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity. Stem Cell Res. Ther. 6, 11 (2015).
Google Scholar
Krueger, T. E. G., Thorek, D. L. J., Denmeade, S. R., Isaacs, J. T. & Brennen, W. N. Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise. Stem Cells Transl. Med. 7, 651–663 (2018).
Google Scholar
Yin, J. Q., Zhu, J. & Ankrum, J. A. Manufacturing of primed mesenchymal stromal cells for therapy. Nat. Biomed. Eng. 3, 90–104 (2019).
Google Scholar
Ungerechts, G. et al. Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses. Mol. Ther. Methods Clin. Dev. 3, 16018 (2016).
Google Scholar
Chen, H., Marino, S. & Ho, C. Y. 97. Large scale purification of AAV with continuous flow ultracentrifugation. Mol. Ther. 24, S42 (2016).
Vazquez-Lombardi, R., Roome, B. & Christ, D. Molecular engineering of therapeutic cytokines. Antibodies 2, 426–451 (2013).
Wigler, M. H., Neugut, A. I. & Weinstein, I. B. Enucleation of mammalian cells in suspension. Methods Cell. Biol. 14, 87–93 (1976).
Google Scholar
Bartosh, T. J. & Ylostalo, J. H. Preparation of anti-inflammatory mesenchymal stem/precursor cells (MSCs) through sphere formation using hanging-drop culture technique. Curr. Protoc. Stem Cell Biol. 28, Unit 2B.6 (2014).
Google Scholar
Frith, J. E., Thomson, B. & Genever, P. G. Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng. Part C. Methods 16, 735–749 (2010).
Google Scholar
Egger, D., Tripisciano, C., Weber, V., Dominici, M. & Kasper, C. Dynamic cultivation of mesenchymal stem cell aggregates. Bioengineering 5, 48 (2018).
Google Scholar
Davidson, P. M., Sliz, J., Isermann, P., Denais, C. & Lammerding, J. Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr. Biol. 7, 1534–1546 (2015).
Google Scholar
Hyduk, S. J. et al. Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation. J. Immunol. 187, 4360–4368 (2011).
Google Scholar
Semon, J. A. et al. Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels. Cell Tissue Res. 341, 147–158 (2010).
Google Scholar
Quah, B. J., Warren, H. S. & Parish, C. R. Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat. Protoc. 2, 2049–2056 (2007).
Google Scholar
Jing, D. et al. Tissue clearing of both hard and soft tissue organs with the PEGASOS method. Cell Res. 28, 803–818 (2018).
Google Scholar
Corradetti, B. et al. Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation. Sci. Rep. 7, 7991 (2017).
Google Scholar
