Generation of large datasets for adenine- and cytidine base editing via high-throughput screening with self-targeting libraries To capture base editing outcomes of SpCas9 CBEs and ABEs across thousands of sites…
SARS-CoV-2 RNA is highly structured in host cells To study the secondary structures of SARS-CoV-2 RNAs inside cells, we infected Vero-E6 cells with WT and Δ382 SARS-CoV-2 and performed structure…
1. Kamat, V. & Rafique, A. Extending the throughput of Biacore 4000 biosensor to accelerate kinetic analysis of antibody-antigen interaction. Anal. Biochem. 530, 75–86 (2017). CAS Article Google Scholar 2.…
Elaborately designed DNA icosahedral shells cage intact virions to effectively protect host cells from viral infections. Emerging and re-emerging viral diseases present significant threats to public health, as witnessed by…
DNA is much more than the genetic information it carries. It is a versatile material for creating systems with tailor-made functionalities that are having an important impact in emerging technologies.…
1. Pollard, A. J. & Bijker, E. M. A guide to vaccinology: from basic principles to new developments. Nat. Rev. Immunol. 21, 83–100 (2021). CAS PubMed Article PubMed Central Google…
A team of researchers at Massachusetts General Hospital (MGH), Boston University School of Public Health (BUSPH), and other institutions have identified more than two dozen genetic regions that may affect…
The old adage “never let them see you sweat,” doesn’t apply in the electrical and computer engineering lab of Rose Faghih, assistant professor of electrical and computer engineering in the…
Previous research has shown that the spike (S) protein of -CoV-2 binds to a host cell receptor, facilitating viral entry. Research has also shown that SARS-CoV-2 variants that lose the…
An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to…
