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Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration

Reagents and materials Gelatin from porcine skin, paraffin oil, SPAN80, EDC, and N-hydroxysuccinimide (NHS) were purchased from Sigma-Aldrich (USA). Glutaraldehyde and acetone were purchased from Daejung Chemicals and Metals (South…

Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice

LPPO The second generation LPPO DR-6180 (Fig. S4) was synthesized in multigram quantities according to the procedure reported previously6. Nanofibrous materials preparation and loading with LPPO Nanofibrous wound dressings were prepared…

Epilepsy brain implant does not transform patients’ sense of self or personality but offers them new insights into illness, study shows — ScienceDaily

A next-generation brain implant currently in clinical use for treating refractory epilepsy — to help prevent symptoms including seizures — does not induce changes to patients’ personalities or self-perceptions, a…

Researchers use artificial intelligence to predict which COVID-19 patients will need a ventilator to breathe — ScienceDaily

Researchers at Case Western Reserve University have developed an online tool to help medical staff quickly determine which COVID-19 patients will need help breathing with a ventilator. The tool, developed…

Study in mice and human tissue is the first to show how a disease mutation weakens barrier properties of epithelial cells lining the gut — ScienceDaily

A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in…