Kambham, N., Markowitz, G. S., Valeri, A. M., Lin, J. & D’Agati, V. D. Obesity-related glomerulopathy: an emerging epidemic. Kidney Int. 59, 1498–1509 (2001).
Google Scholar
Saran, R. et al. US Renal Data System 2018 annual data report: epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 73, A7–A8 (2019).
Google Scholar
Naqvi, R. Glomerulonephritis contributing to chronic kidney disease. Urol. Nephrol. Open Access. J. 5(4), 00179 (2017).
Ziółkowska, H., Adamczuk, D., Leszczyńska, B. & Roszkowska-Blaim, M. Glomerulopathies as causes of end-stage renal disease in children [Polish]. Pol. Merkur. Lekarski. 26, 301–305 (2009).
Google Scholar
Moxey-Mims, M. M. et al. Glomerular diseases: registries and clinical trials. Clin. J. Am. Soc. Nephrol. 11, 2234–2243 (2016).
Google Scholar
Petrosyan, A. et al. A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nat. Commun. 10, 3656 (2019).
Google Scholar
Bonventre, J. V., Vaidya, V. S., Schmouder, R., Feig, P. & Dieterle, F. Next-generation biomarkers for detecting kidney toxicity. Nat. Biotechnol. 28, 436–440 (2010).
Google Scholar
Cieslinski, D. A. & David Humes, H. Tissue engineering of a bioartificial kidney. Biotechnol. Bioeng. 43, 678–681 (1994).
Google Scholar
Musah, S., Dimitrakakis, N., Camacho, D. M., Church, G. M. & Ingber, D. E. Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a glomerulus chip. Nat. Protoc. 13, 1662–1685 (2018).
Google Scholar
Sánchez-Romero, N., Schophuizen, C. M. S., Giménez, I. & Masereeuw, R. In vitro systems to study nephropharmacology: 2D versus 3D models. Eur. J. Pharmacol. 790, 36–45 (2016).
Google Scholar
Vimtrup, B. On the number, shape, structure, and surface area of the glomeruli in the kidneys of man and mammals. Am. J. Anat. 41, 123–151 (1928).
D’Amico, G. & Bazzi, C. Pathophysiology of proteinuria. Kidney Int. 63, 809–825 (2003).
Google Scholar
Neal, C. R. et al. Novel hemodynamic structures in the human glomerulus. Am. J. Physiol. -Ren. Physiol. 315, F1370–F1384 (2018).
Capasso, G., Trepiccione, F. & Zacchia, M. in Critical Care Nephrology 3rd edn Ch. 8 (eds Ronco, C., Bellomo, R., Kellum, J. A. & Ricci, Z.) 42–48.e1 (Elsevier, 2019).
Arendshorst, W. J. & Bello-Reuss, E. in Handbook of Cell Signaling 2nd edn Ch. 318 (eds Bradshaw, R. A. & Dennis, E. A.) 2707–2731 (Academic, 2010).
Maezawa, Y., Cina, D. & Quaggin, S. E. in Seldin and Giebisch’s The Kidney 5th edn Ch. 22 (eds Alpern, R. J., Moe, O. W. & Caplan, M.) 721–755 (Academic, 2013).
Miner, J. H. Renal basement membrane components. Kidney Int. 56, 2016–2024 (1999).
Google Scholar
Rabelink, T. J., Heerspink, H. J. L. & de Zeeuw, D. in Chronic Renal Disease Ch. 9 (eds Kimmel, P. L. & Rosenberg, M. E.) 92–105 (Academic, 2015).
Chung, J. J. et al. Single-cell transcriptome profiling of the kidney glomerulus identifies key cell types and reactions to injury. J. Am. Soc. Nephrol. 31, 2341–2354 (2020).
Google Scholar
Karaiskos, N. et al. A single-cell transcriptome atlas of the mouse glomerulus. J. Am. Soc. Nephrol. 29, 2060–2068 (2018).
Google Scholar
Arar, M. et al. Platelet-derived growth factor receptor β regulates migration and DNA synthesis in metanephric mesenchymal cells. J. Biol. Chem. 275, 9527–9533 (2000).
Google Scholar
Kamel, K. S. & Halperin, M. L. in Fluid, Electrolyte and Acid-Base Physiology 5th edn Ch. 9 (eds Kamel, K. S. & Halperin, M. L.) 215–263 (Elsevier, 2017).
Iversen, B. M. & Ofstad, J. The effect of hypertension on glomerular structures and capillary permeability in passive Heymann glomerulonephritis. Microvascular Res. 34, 137–151 (1987).
Google Scholar
Briggs, J. P., Kriz, W. & Schnermann, J. B. in National Kidney Foundation’s Primer on Kidney Diseases 6th edn (eds Gilbert, S. J., Weiner, D. E., Gipson, D. S., Perazella, M. A. & Tonelli, M.) 2–18 (Elsevier, 2014).
Satchell, S. C. & Braet, F. Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier. Am. J. Physiol. Ren. Physiol. 296, F947–F956 (2009).
Google Scholar
Haraldsson, B. & Nyström, J. The glomerular endothelium: new insights on function and structure. Curr. Opin. Nephrol. Hypertens. 21, 258–263 (2012).
Google Scholar
Dean, D. F. & Molitoris, B. A. in Critical Care Nephrology 3rd edn Ch. 7 (eds Ronco, C., Bellomo, R., Kellum, J. A. & Ricci, Z.) 35–42.e2 (Elsevier, 2019).
Pollak, M. R., Quaggin, S. E., Hoenig, M. P. & Dworkin, L. D. The glomerulus: the sphere of influence. Clin. J. Am. Soc. Nephrol. 9, 1461–1469 (2014).
Google Scholar
Abrahamson, D. R., st. John, P. L., Stroganova, L., Zelenchuk, A. & Steenhard, B. M. Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes. J. Histochem. Cytochem. 61, 706–718 (2013).
Google Scholar
Feher, J. Quantitative Human Physiology 2nd edn 705–714 (Academic, 2017).
Garg, P. A review of podocyte biology. Am. J. Nephrol. 47, 3–13 (2018).
Google Scholar
Oddsson, Á., Patrakka, J. & Tryggvason, K. Glomerular filtration barrier: From Molecular Biology to Regulation Mechanisms. Reference Module in Biomedical Sciences (Elsevier, 2014).
Garg, P. & Rabelink, T. Glomerular proteinuria: a complex interplay between unique players. Adv. Chronic Kidney Dis. 18, 233–242 (2011).
Google Scholar
Moorthy, A. V. & Blichfeldt, T. C. in Pathophysiology of Kidney Disease and Hypertension (ed. Moorthy, A. V.) 1–15 (Saunders, 2009).
Reiser, J. & Altintas, M. M. Podocytes. F1000Res. 5, 114 (2016).
Kriz, W. & Elger, M. in Comprehensive Clinical Nephrology 4th edn Ch. 1 (eds Floege, J., Johnson, R. J. & Feehally, J.) 3–14 (Mosby, 2010).
Nikolic, M., Sustersic, T. & Filipovic, N. In vitro models and on-chip systems: biomaterial interaction studies with tissues generated using lung epithelial and liver metabolic cell lines. Front. Bioeng. Biotechnol. 6, 120 (2018).
Google Scholar
Wang, K., Shindoh, H., Inoue, T. & Horii, I. Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines. J. Toxicol. Sci. 27, 229–237 (2002).
Google Scholar
Wragg, N. M., Burke, L. & Wilson, S. L. A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations. Ren. Replace. Ther. 5, 18 (2019).
Ali, M. et al. A photo-crosslinkable kidney ECM-derived bioink accelerates renal tissue formation. Adv. Healthc. Mater. 8, e1800992 (2019).
Google Scholar
Slater, S. C. et al. An in vitro model of the glomerular capillary wall using electrospun collagen nanofibres in a bioartificial composite basement membrane. PLoS ONE 6, e20802 (2011).
Google Scholar
Li, Z. et al. Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes. Acta Biomater. 78, 111–122 (2018).
Google Scholar
Tuffin, J. et al. A composite hydrogel scaffold permits self-organization and matrix deposition by cocultured human glomerular cells. Adv. Healthc. Mater. 8, 1900698 (2019).
Waters, J. P. et al. A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis. J. Pathol. 243, 390–400 (2017).
Google Scholar
Musah, S. et al. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat. Biomed. Eng. 1, 0069 (2017).
Google Scholar
Becker, G. J. & Hewitson, T. D. Animal models of chronic kidney disease: useful but not perfect. Nephrol. Dial. Transplant. 28, 2432–2438 (2013).
Google Scholar
Hewitson, T. D., Ono, T. & Becker, G. J. Small animal models of kidney disease: a review. Methods Mol. Biol. 466, 41–57 (2009).
Google Scholar
Shankland, S. J. The podocyte’s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 69, 2131–2147 (2006).
Google Scholar
Shankland, S. J., Pippin, J. W., Reiser, J. & Mundel, P. Podocytes in culture: past, present, and future. Kidney Int. 72, 26–36 (2007).
Google Scholar
Yoshimura, Y. et al. Manipulation of nephron-patterning signals enables selective induction of podocytes from human pluripotent stem cells. J. Am. Soc. Nephrol. 30, 304–321 (2019).
Google Scholar
Hale, L. J. et al. 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat. Commun. 9, 5167 (2018).
Google Scholar
Higgins, J. W. et al. Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening. Preprint at bioRxiv https://doi.org/10.1101/505396 (2018).
Google Scholar
Edmondson, R., Broglie, J. J., Adcock, A. F. & Yang, L. Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors. Assay. Drug Dev. Technol. 12, 207–218 (2014).
Google Scholar
Chaicharoenaudomrung, N., Kunhorm, P. & Noisa, P. Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling. World J. Stem Cell 11, 1065–1083 (2019).
Schmid, J. et al. A perfusion bioreactor system for cell seeding and oxygen-controlled cultivation of three-dimensional cell cultures. Tissue Eng. Part C. Methods 24, 585–595 (2018).
Google Scholar
Lovett, M., Lee, K., Edwards, A. & Kaplan, D. L. Vascularization strategies for tissue engineering. Tissue Eng. Part B Rev. 15, 353–370 (2009).
Google Scholar
Wu, H. & Humphreys, B. D. Single cell sequencing and kidney organoids generated from pluripotent stem cells. Clin. J. Am. Soc. Nephrol. 15, 550–556 (2020).
Google Scholar
Pebworth, M.-P., Cismas, S. A. & Asuri, P. A novel 2.5D culture platform to investigate the role of stiffness gradients on adhesion-independent cell migration. PLoS ONE 9, e110453 (2014).
Google Scholar
Langhans, S. A. Three-dimensional in vitro cell culture models in drug discovery and drug repositioning. Front. Pharmacol. 9, 6 (2018).
Google Scholar
Reiser, J. & Sever, S. Podocyte biology and pathogenesis of kidney disease. Annu. Rev. Med. 64, 357–366 (2013).
Google Scholar
Jang, K. J. & Suh, K. Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab. Chip 10, 36–42 (2010).
Google Scholar
Friedrich, C., Endlich, N., Kriz, W. & Endlich, K. Podocytes are sensitive to fluid shear stress in vitro. Am. J. Physiol. Ren. Physiol. 291, F856–F865 (2006).
Google Scholar
Wang, L. et al. A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice. Lab. Chip 17, 1749–1760 (2017).
Google Scholar
Xie, R. et al. h-FIBER: microfluidic topographical hollow fiber for studies of glomerular filtration barrier. ACS Cent. Sci. 6, 903–912 (2020).
Google Scholar
Zhou, M. et al. Development of a functional glomerulus at the organ level on a chip to mimic hypertensive nephropathy. Sci. Rep. 6, 31771 (2016).
Google Scholar
Wilmer, M. J. et al. Kidney-on-a-chip technology for drug-induced nephrotoxicity screening. Trends Biotechnol. 34, 156–170 (2016).
Google Scholar
Toda, N. et al. Crucial role of mesangial cell-derived connective tissue growth factor in a mouse model of anti-glomerular basement membrane glomerulonephritis. Sci. Rep. 7, 42114 (2017).
Google Scholar
Tung, C.-W., Hsu, Y.-C., Shih, Y.-H., Chang, P.-J. & Lin, C.-L. Glomerular mesangial cell and podocyte injuries in diabetic nephropathy. Nephrology 23, 32–37 (2018).
Google Scholar
Homan, K. A. et al. Flow-enhanced vascularization and maturation of kidney organoids in vitro. Nat. Methods 16, 255–262 (2019).
Google Scholar
Ashammakhi, N., Wesseling-Perry, K., Hasan, A., Elkhammas, E. & Zhang, Y. S. Kidney-on-a-chip: untapped opportunities. Kidney Int. 94, 1073–1086 (2018).
Google Scholar
Tanyeri, M. & Tay, S. Viable cell culture in PDMS-based microfluidic devices. Methods Cell Biol. 148, 3–33 (2018).
Google Scholar
Gokaltun, A., Yarmush, M. L., Asatekin, A. & Usta, O. B. Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology. Technology 5, 1–12 (2017).
Google Scholar
Pourmand, A. et al. Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump. Sens. Actuators B Chem. 262, 625–636 (2018).
Google Scholar
Novak, R. et al. Robotic fluidic coupling and interrogation of multiple vascularized organ chips. Nat. Biomed. Eng. 4, 407–420 (2020).
Google Scholar
Shaegh, S. A. M. et al. Rapid prototyping of whole-thermoplastic microfluidics with built-in microvalves using laser ablation and thermal fusion bonding. Sens. Actuators B Chem. 255, 100–109 (2018).
Google Scholar
Gomez-Sjoberg, R., Leyrat, A. A., Houseman, B. T., Shokat, K. & Quake, S. R. Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications. Anal. Chem. 82, 8954–8960 (2010).
Google Scholar
Paoli, R. & Samitier, J. Mimicking the kidney: a key role in organ-on-chip development. Micromachines 7, 126 (2016).
Google Scholar
Bhattacharjee, N., Parra-Cabrera, C., Kim, Y. T., Kuo, A. P. & Folch, A. Desktop-stereolithography 3D-printing of a polydimethylsiloxane)-based material with Sylgard-184 properties. Adv. Mater. 30, e1800001 (2018).
Google Scholar
Zhang, Y. S. & Khademhosseini, A. Advances in engineering hydrogels. Science 356, eaaf3627 (2017).
Google Scholar
Lü, S. H. et al. Self-assembly of renal cells into engineered renal tissues in collagen/matrigel scaffold in vitro. J. Tissue Eng. Regen. Med. 6, 786–792 (2012).
Google Scholar
Wang, P. C. Reconstruction of renal glomerular tissue using collagen vitrigel scaffold. J. Biosci. Bioeng. 99, 529–540 (2005).
Google Scholar
Pullela, S. R. et al. Permselectivity replication of artificial glomerular basement membranes in nanoporous collagen multilayers. J. Phys. Chem. Lett. 2, 2067–2072 (2011).
Google Scholar
Finesilver, G., Bailly, J., Kahana, M. & Mitrani, E. Kidney derived micro-scaffolds enable HK-2 cells to develop more in-vivo like properties. Exp. Cell Res. 322, 71–80 (2014).
Google Scholar
Du, C. et al. Functional kidney bioengineering with pluripotent stem-cell-derived renal progenitor cells and decellularized kidney scaffolds. Adv. Healthc. Mater. 5, 2080–2091 (2016).
Google Scholar
Singh, N. K. et al. Three-dimensional cell-printing of advanced renal tubular tissue analogue. Biomaterials 232, 119734 (2020).
Google Scholar
Yin, X. et al. Engineering stem cell organoids. Cell Stem Cell 18, 25–38 (2016).
Google Scholar
Freedman, B. S. et al. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat. Commun. 6, 8715 (2015).
Google Scholar
Morizane, R. et al. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat. Biotechnol. 33, 1193–1200 (2015).
Google Scholar
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).
Google Scholar
Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53–67 (2014).
Google Scholar
Bantounas, I. et al. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors. Stem Cell Rep. 10, 766–779 (2018).
Kim, Y. K. et al. Gene-edited human kidney organoids reveal mechanisms of disease in podocyte development. Stem Cell 35, 2366–2378 (2017).
Google Scholar
Sharmin, S. et al. Human induced pluripotent stem cell-derived podocytes mature into vascularized glomeruli upon experimental transplantation. J. Am. Soc. Nephrol. 27, 1778–1791 (2016).
Google Scholar
van den Berg, C. W. et al. Renal subcapsular transplantation of PSC-derived kidney organoids induces neo-vasculogenesis and significant glomerular and tubular maturation in vivo. Stem Cell Rep. 10, 751–765 (2018).
Geuens, T., van Blitterswijk, C. A. & LaPointe, V. L. S. Overcoming kidney organoid challenges for regenerative medicine. NPJ Regen. Med. 5, 8 (2020).
Google Scholar
Combes, A. N., Zappia, L., Er, P. X., Oshlack, A. & Little, M. H. Single-cell analysis reveals congruence between kidney organoids and human fetal kidney. Genome Med. 11, 3 (2019).
Google Scholar
Garreta, E. et al. Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. Nat. Mater. 18, 397–405 (2019).
Google Scholar
Czerniecki, S. M. et al. High-throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping. Cell Stem Cell 22, 929–940.e4 (2018).
Google Scholar
Low, J. H. et al. Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell 25, 373–387.e9 (2019).
Google Scholar
Serluca, F. C., Drummond, I. A. & Fishman, M. C. Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces. Curr. Biol. 12, 492–497 (2002).
Google Scholar
Morizane, R. & Bonventre, J. V. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat. Protoc. 12, 195–207 (2017).
Google Scholar
Tanigawa, S. et al. Organoids from nephrotic disease-derived iPSCs identify impaired NEPHRIN localization and slit diaphragm formation in kidney podocytes. Stem Cell Rep. 11, 727–740 (2018).
Google Scholar
Morizane, R. & Bonventre, J. V. Kidney organoids: a translational journey. Trends Mol. Med. 23, 246–263 (2017).
Google Scholar
Kim, J., Koo, B.-K. & Knoblich, J. A. Human organoids: model systems for human biology and medicine. Nat. Rev. Mol. Cell Biol. 21, 571–584 (2020).
Google Scholar
McGuigan, A. P. & Sefton, M. V. Vascularized organoid engineered by modular assembly enables blood perfusion. Proc. Natl Acad. Sci. USA 103, 11461–11466 (2006).
Google Scholar
van den Berg, C. W., Koudijs, A., Ritsma, L. & Rabelink, T. J. In vivo assessment of size-selective glomerular sieving in transplanted human induced pluripotent stem cell-derived kidney organoids. J. Am. Soc. Nephrol. 31, 921–929 (2020).
Google Scholar
Ye, S. et al. A chemically defined hydrogel for human liver organoid culture. Adv. Funct. Mater. 30, 2000893 (2020).
Google Scholar
Curvello, R., Alves, D., Abud, H. E. & Garnier, G. A thermo-responsive collagen-nanocellulose hydrogel for the growth of intestinal organoids. Mater. Sci. Eng. C. 124, 112051 (2021).
Google Scholar
Agarwal, T., Celikkin, N., Costantini, M., Maiti, T. K. & Makvandi, P. Recent advances in chemically defined and tunable hydrogel platforms for organoid culture. Bio-Des. Manuf. 4, 641–674 (2021).
Hynds, R. E., Bonfanti, P. & Janes, S. M. Regenerating human epithelia with cultured stem cells: feeder cells, organoids and beyond. EMBO Mol. Med. 10, 139–150 (2018).
Google Scholar
Nicodemus, G. D. & Bryant, S. J. Cell encapsulation in biodegradable hydrogels for tissue engineering applications. Tissue Eng. Part B Rev. 14, 149–165 (2008).
Google Scholar
Murphy, S. V. & Atala, A. 3D bioprinting of tissues and organs. Nat. Biotechnol. 32, 773–785 (2014).
Google Scholar
Zhang, Y. S. et al. 3D bioprinting for tissue and organ fabrication. Ann. Biomed. Eng. 45, 148–163 (2017).
Google Scholar
Gungor-Ozkerim, P. S., Inci, I., Zhang, Y. S., Khademhosseini, A. & Dokmeci, M. R. Bioinks for 3D bioprinting: an overview. Biomater. Sci. 6, 915–946 (2018).
Google Scholar
Homan, K. A. et al. Bioprinting of 3D convoluted renal proximal tubules on perfusable chips. Sci. Rep. 6, 34845 (2016).
Google Scholar
Grigoryan, B. et al. Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science 364, 458–464 (2019).
Google Scholar
Mandrycky, C., Wang, Z., Kim, K. & Kim, D. H. 3D bioprinting for engineering complex tissues. Biotechnol. Adv. 34, 422–434 (2016).
Google Scholar
Lawlor, K. T. et al. Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation. Nat. Mater. 20, 260–271 (2020).
Google Scholar
Miri, A. K. et al. Effective bioprinting resolution in tissue model fabrication. Lab. Chip 19, 2019–2037 (2019).
Google Scholar
Heinrich, M. A. et al. 3D bioprinting: from benches to translational applications. Small 15, e1805510 (2019).
Google Scholar
Moroni, L. et al. Biofabrication strategies for 3D in vitro models and regenerative medicine. Nat. Rev. Mater. 3, 21–37 (2018).
Google Scholar
Li, W. et al. Recent advances in formulating and processing biomaterial inks for vat polymerization-based 3D printing. Adv. Healthc. Mater. 9, 2000156 (2020).
Google Scholar
Zhu, Z., Ng, D. W. H., Park, H. S. & McAlpine, M. C. 3D-printed multifunctional materials enabled by artificial-intelligence-assisted fabrication technologies. Nat. Rev. Mater. 6, 27–47 (2020).
Xie, L. et al. Micro-CT imaging and structural analysis of glomeruli in a model of adriamycin-induced nephropathy. Am. J. Physiol. Ren. Physiol. 316, F76–F89 (2019).
Google Scholar
Zhang, K. et al. 3D bioprinting of urethra with PCL/PLCL blend and dual autologous cells in fibrin hydrogel: an in vitro evaluation of biomimetic mechanical property and cell growth environment. Acta Biomater. 50, 154–164 (2017).
Google Scholar
Zhang, Y. S. et al. 3D extrusion bioprinting methods. Nat. Rev. Methods Primers 1, 75 (2021).
Li, X. et al. Inkjet bioprinting of biomaterials. Chem. Rev. 120, 10793–10833 (2020).
Google Scholar
Bishop, E. S. et al. 3-D bioprinting technologies in tissue engineering and regenerative medicine: current and future trends. Genes Dis. 4, 185–195 (2017).
Google Scholar
Ravanbakhsh, H. et al. Emerging technologies in multi-material bioprinting. Adv. Mater. 33, 2104730 (2021).
Google Scholar
Liu.W. et al. Rapid continuous multimaterial extrusion bioprinting. Adv. Mater. 29(3), 1604630 (2017).
Kolesky, D. B. et al. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv. Mater. 26, 3124–3130 (2014).
Google Scholar
Xu, T. et al. Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology. Biomaterials 34, 130–139 (2013).
Google Scholar
Miri, A. K. et al. Microfluidics-enabled multimaterial maskless stereolithographic bioprinting. Adv. Mater. 30, e1800242 (2018).
Google Scholar
Ma, X. et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc. Natl Acad. Sci. USA 113, 2206–2211 (2016).
Google Scholar
Zhu, W. et al. Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. Biomaterials 124, 106–115 (2017).
Google Scholar
Gong, J. et al. Complexation-induced resolution enhancement of 3D-printed hydrogel constructs. Nat. Commun. 11, 1267 (2020).
Google Scholar
Lee, J. M. & Yeong, W. Y. Design and printing strategies in 3D bioprinting of cell-hydrogels: a review. Adv. Healthc. Mater. 5, 2856–2865 (2016).
Google Scholar
Duan, B. State-of-the-art review of 3D bioprinting for cardiovascular tissue engineering. Ann. Biomed. Eng. 45, 195–209 (2017).
Google Scholar
Fogo, A. B. & Kon, V. The glomerulus–a view from the inside–the endothelial cell. Int. J. Biochem. Cell Biol. 42, 1388–1397 (2010).
Google Scholar
Aguado, B. A., Mulyasasmita, W., Su, J., Lampe, K. J. & Heilshorn, S. C. Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng. Part A 18, 806–815 (2012).
Google Scholar
Rayner, S. G. et al. Multiphoton-guided creation of complex organ-specific microvasculature. Adv. Healthc. Mater. 10, e2100031 (2021).
Google Scholar
Brassard, J. A., Nikolaev, M., Hübscher, T., Hofer, M. & Lutolf, M. P. Recapitulating macro-scale tissue self-organization through organoid bioprinting. Nat. Mater. 20, 22–29 (2021).
Google Scholar
Zanella, F., Lorens, J. B. & Link, W. High content screening: seeing is believing. Trends Biotechnol. 28, 237–245 (2010).
Google Scholar
Li, S. & Xia, M. Review of high-content screening applications in toxicology. Arch. Toxicol. 93, 3387–3396 (2019).
Google Scholar
Boreström, C. et al. A CRISP(e)R view on kidney organoids allows generation of an induced pluripotent stem cell-derived kidney model for drug discovery. Kidney Int. 94, 1099–1110 (2018).
Google Scholar
Zhang, Y. S. et al. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proc. Natl Acad. Sci. USA 114, E2293–E2302 (2017).
Google Scholar
Aleman, J., Kilic, T., Mille, L. S., Shin, S. R. & Zhang, Y. S. Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices. Nat. Protoc. 16, 2564–2593 (2021).
Google Scholar
Abdallah, M. et al. Influence of hydrolyzed polyacrylamide hydrogel stiffness on podocyte morphology, phenotype, and mechanical properties. ACS Appl. Mater. Interfaces 11, 32623–32632 (2019).
Google Scholar
Nakao, Y., Kimura, H., Sakai, Y. & Fujii, T. Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device. Biomicrofluidics 5, 022212 (2011).
Google Scholar
Huh, D. et al. Reconstituting organ-level lung functions on a chip. Science 328, 1662–1668 (2010).
Google Scholar
Tran, T. et al. In vivo developmental trajectories of human podocyte inform in vitro differentiation of pluripotent stem cell-derived podocytes. Dev. Cell 50, 102–116.e6 (2019).
Google Scholar
Ng, C. P., Zhuang, Y., Lin, A. W. H. & Teo, J. C. M. A fibrin-based tissue-engineered renal proximal tubule for bioartificial kidney devices: development, characterization and in vitro transport study. Int. J. Tissue Eng. 2013, 319476 (2013).
Chevtchik, N. V. et al. Upscaling of a living membrane for bioartificial kidney device. Eur. J. Pharmacol. 790, 28–35 (2016).
Google Scholar
