June, C. H., O’Connor, R. S., Kawalekar, O. U., Ghassemi, S. & Milone, M. C. CAR T cell immunotherapy for human cancer. Science 359, 1361–1365 (2018).
Google Scholar
Chmielewski, M., Hombach, A. A. & Abken, H. Antigen-specific T-cell activation independently of the MHC: chimeric antigen receptor-redirected T cells. Front. Immunol. 4, 371 (2013).
Google Scholar
Grupp, S. A. et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368, 1509–1518 (2013).
Google Scholar
Maude, S. L. et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N. Engl. J. Med. 378, 439–448 (2018).
Google Scholar
Sadelain, M., Brentjens, R. & Riviere, I. The basic principles of chimeric antigen receptor design. Cancer Discov. 3, 388–398 (2013).
Google Scholar
Kochenderfer, J. N. et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119, 2709–2720 (2012).
Google Scholar
Neelapu, S. S. et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N. Engl. J. Med. 377, 2531–2544 (2017).
Google Scholar
Kennedy, M. J. et al. Rapid blue-light-mediated induction of protein interactions in living cells. Nat. Methods 7, 973–975 (2010).
Google Scholar
Guntas, G. et al. Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proc. Natl Acad. Sci. USA 112, 112–117 (2015).
Google Scholar
He, L. et al. Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. Elife https://doi.org/10.7554/eLife.10024 (2015).
Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730–732 (1999).
Google Scholar
Wu, C. Y., Roybal, K. T., Puchner, E. M., Onuffer, J. & Lim, W. A. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science 350, aab4077 (2015).
Google Scholar
Irving, B. A., Chan, A. C. & Weiss, A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J. Exp. Med. 177, 1093–1103 (1993).
Google Scholar
Zimmerman, S. P. et al. Tuning the binding affinities and reversion kinetics of a light inducible dimer allows control of transmembrane protein localization. Biochemistry 55, 5264–5271 (2016).
Google Scholar
Chen, J. et al. NR4A transcription factors limit CAR T cell function in solid tumours. Nature 567, 530–534 (2019).
Google Scholar
Maraskovsky, E., Chen, W. F. & Shortman, K. IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells. J. Immunol. 143, 1210–1214 (1989).
Google Scholar
Yu, N. et al. Near-infrared-light activatable nanoparticles for deep-tissue-penetrating wireless optogenetics. Adv. Healthc. Mater. 8, e1801132 (2019).
Google Scholar
Tan, P., He, L., Han, G. & Zhou, Y. Optogenetic immunomodulation: shedding light on antitumor immunity. Trends Biotechnol. 35, 215–226 (2017).
Google Scholar
Nguyen, N. T. et al. CRAC channel-based optogenetics. Cell Calcium 75, 79–88 (2018).
Google Scholar
Huang, K., Jayakumar, M. K. G. & Zhang, Y. Lutetium doping for making big core and core-shell upconversion nanoparticles. J. Mater. Chem. C 3, 10267–10272 (2015).
Google Scholar
Barolet, D. Light-emitting diodes (LEDs) in dermatology. Semin Cutan. Med. Surg. 27, 227–238 (2008).
Google Scholar
Pan, Y. et al. Mechanogenetics for the remote and noninvasive control of cancer immunotherapy. Proc. Natl Acad. Sci. USA 115, 992–997 (2018).
Google Scholar
Ma, Y. et al. Targeting of antigens to B lymphocytes via CD19 as a means for tumor vaccine development. J. Immunol. 190, 5588–5599 (2013).
Google Scholar
Dai, H., Wang, Y., Lu, X. & Han, W. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. https://doi.org/10.1093/jnci/djv439 (2016)
Lee, D. W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 385, 517–528 (2015).
Google Scholar
Maude, S. L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507–1517 (2014).
Google Scholar
Giavridis, T. et al. CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade. Nat. Med. 24, 731–738 (2018).
Google Scholar
Allen, M. E. et al. An AND-gated drug and photoactivatable Cre-loxP system for spatiotemporal control in cell-based therapeutics. ACS Synth. Biol. 8, 2359–2371 (2019).
Google Scholar
Huang, Z. et al. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci. Adv. 6, eaay9209 (2020).
Google Scholar

